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Adhesive applicator with polymerization agent and/or bioactive material

A bioactive substance and applicator technology, applied in surgical adhesives, medical science, surgery, etc., can solve problems such as inability to provide a way to control the polymerization process rate, inconvenient application of adhesive compositions, etc.

Inactive Publication Date: 2001-06-13
CLOSURE MEDICAL CORP (US)
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0020] All of these methods involve combining cyanoacrylate adhesives with bioactive materials, the disclosed methods are inconvenient for applying the adhesive composition as multiple solutions and / or applicators are required to mix the initiator and adhesive compositions may not provide a way to control the rate of the polymerization process
Additionally, the choice of bioactive materials is limited by the desire to avoid reactions between the adhesive and the bioactive material

Method used

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  • Adhesive applicator with polymerization agent and/or bioactive material
  • Adhesive applicator with polymerization agent and/or bioactive material
  • Adhesive applicator with polymerization agent and/or bioactive material

Examples

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Embodiment Construction

[0056] As noted above, commonly assigned PCT Application No. WO 96 / 40797, the disclosure of which is incorporated herein by reference in its entirety, discloses the use of low boiling point solvents, such as acetone, ethanol, or mixtures thereof, to combine polymerization or crosslinking initiators or rate The conditioner is applied to the applicator tip. Cyanoacrylate adhesive compositions applied through such (applicator) tips exhibit rapid polymerization with concomitant heat generation. If the composition is applied to living tissue, it may cause damage to the tissue and necrosis of the underlying and / or surrounding living matter in the following experiments. Analysis of the (applicator) tip by the method of WO 96 / 40707 shows that application of an initiator or rate modifier to the (applicator) tip with acetone will result in a distribution of material mainly outside the (applicator) tip The exterior or vicinity of, and near or bottom of, some portion of a surface. Such ...

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PUM

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Abstract

A method of applying a bioactive agent and / or a polymerization or cross-linking rate modifier and / or a polymerization initiator to an applicator tip includes dissolving or dispersing the rate modifier, the initiator, and / or the bioactive agent in a low boiling point solvent, applying the resulting solution or dispersion to the applicator tip, and drying the applicator tip. The initiator and / or rate modifier is preferably applied in a methanol solvent and distributed along a concentration gradient on the applicator tip.

Description

Background of the invention [0001] 1. field of invention [0002] The present invention relates to applicators for biomedical adhesives and sealants, methods of making them and methods of using these adhesives and sealants. In particular, the present invention relates to methods of applying bioactive agents, polymerization rate modifiers, and / or polymerization initiators to applicator tips; applicators and applicator tips made by these methods; and applying such Applicators are used in medical, surgical and other topical methods. [0003] 2. Description of related fields [0004] The first products used for wound closure were surgical sutures and staples. The sutures are believed to provide adequate wound support. However, sutures cause additional trauma to the wound site (due to the need to pass the needle and suture through the tissue, and the need for a puncture needle to anesthetize the wound), are time consuming, and cause unsightly marks of wound closure at the ski...

Claims

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Application Information

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IPC IPC(8): A61B17/00A61L24/00A61L24/06
CPCA61L2300/404A61L2300/406A61B17/00491A61L2300/416A61L2300/41A61L2300/402A61L24/06A61L24/0015A61L2300/222C08L35/04
Inventor U·纳兰W·S·C·尼科尔森
Owner CLOSURE MEDICAL CORP (US)
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