Method for preparing bio-degraded polymer particles by supercritical crystallization
A supercritical crystallization and biodegradation technology, applied in the production of bulk chemicals, etc., can solve the problems of purification and complexity of products that consume organic solvents, and achieve the effects of low cost, simple operation and no environmental pollution.
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Embodiment 1
[0016] Introduce high-pressure carbon dioxide into the autoclave, and adjust the temperature and pressure to a steady state (40° C., 10 MPa). Polylactic acid (L-PLA) was dissolved in dichloromethane to form a 10 mg / ml organic solution. The dichloromethane solution of carbon dioxide and polylactic acid was sprayed into the autoclave at the same time, the flow rates were 20ml / min and 5ml / min, and the time was 5 minutes. The multiphase system was mixed and expanded in the autoclave at the same time. After the system was stabilized for about 5 minutes, fresh carbon dioxide was introduced into the autoclave and the high pressure (20Mpa) was maintained for 90 minutes to wash the residual organic solvent. Finally, it was slowly lowered to normal pressure, and the product was collected by opening the kettle. According to the scanning electron microscope (SEM) analysis, the average particle size of polylactic acid was 0.943 μm, which could be directly used to prepare injections, and co...
Embodiment 2
[0018] Introduce high-pressure carbon dioxide into the autoclave, and adjust the temperature and pressure to a steady state (40° C., 10 MPa). Polylactic acid (L-PLA) was dissolved in dichloromethane to form a 20 mg / ml organic solution. The dichloromethane solution of carbon dioxide and polylactic acid was sprayed into the autoclave at the same time, the flow rates were 20ml / min and 5ml / min, and the time was 5 minutes. The multiphase system was mixed and expanded in the autoclave at the same time. After the system was stabilized for about 5 minutes, fresh carbon dioxide was introduced into the autoclave and the high pressure (20Mpa) was maintained for 90 minutes to wash the residual organic solvent. Finally, the pressure was slowly lowered to normal pressure, and the product was collected by opening the kettle. According to the scanning electron microscope (SEM) analysis, the average particle size of polylactic acid was 1.773 μm, which could be directly used to prepare injectio...
Embodiment 3
[0020] Introduce high-pressure carbon dioxide into the autoclave, and adjust the temperature and pressure to a steady state (40° C., 10 MPa). Polylactic acid (L-PLA) was dissolved in dichloromethane to form a 30 mg / ml organic solution. The dichloromethane solution of carbon dioxide and polylactic acid was sprayed into the autoclave at the same time, the flow rates were 20ml / min and 5ml / min, and the time was 5 minutes. The multiphase system was mixed and expanded in the autoclave at the same time. After the system was stabilized for about 5 minutes, fresh carbon dioxide was introduced into the autoclave and the high pressure (20Mpa) was maintained for 90 minutes to wash the residual organic solvent. Finally, it was slowly lowered to normal pressure, and the product was collected by opening the kettle. According to the scanning electron microscope (SEM) analysis, the average particle size of polylactic acid was 2.050 μm, which could be directly used to prepare injections, and co...
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