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Method for producing antibiotic preparation and its application

A technology of antibiotics and preparations, applied in the preparation and application fields of antibiotics preparations

Inactive Publication Date: 2002-11-20
HERAEUS KULZER
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The previous drawback of this system was that for each of the aminoglycosides, lincosamides and tetracyclines used it had to be synthesized into a specific form of salt prior to preparation of long-acting formulations

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Make a mixture with 51mg gentamicin sulfate (700U / mg, Fluka), 51mg sodium lauryl sulfate, 280mg carnauba wax, 1118mg calcium sulfate dihydrate (Fluka) and 1ml water, mix with calcium chloride Homogenize and dry, then grind the mixture obtained. 200 mg of the mixture were each pressed into oblate molded bodies with a diameter of 13 mm within two minutes using a press with a pressure of 5 tons.

Embodiment 2

[0055] Make a mixture with 51mg gentamicin sulfate (700U / mg, Fluka), 51mg sodium lauryl sulfate, 140mg beeswax, 1258mg calcium sulfate dihydrate (Fluka) and 1ml water, mix well with calcium chloride Let dry and grind the mixture obtained. Each 200 mg of the mixture was pressed into oblate molded bodies with a diameter of 13 mm within two minutes using a press with a pressure of 5 tons.

Embodiment 3

[0057] The molded bodies obtained in Examples 1 and 2 were immersed in physiological saline and left at 37°C for 12 days to measure the delayed release of the antibiotic component. After standing for 1, 3, 6, 9 and 12 days, samples were taken for inspection. Through the agar diffusion test, Bacillus subtilis ATCC 6633 was used as the standard microorganism to determine the value of antibiotics (results are shown in Table 1).

[0058] implement

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PUM

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Abstract

The present invention relates to a preparation method and application of an antibiotic preparation used in human medicine and veterinary medicine for treating local microbial infections of hard tissue and soft tissue. The preparation method of the antibiotic preparation of the present invention is as follows: from water and an amphoteric component such as an alkyl sulfate, and one or more antibiotics selected from the group consisting of aminoglycoside antibiotics, lincosamide antibiotics, and tetracycline antibiotics The components, an organic auxiliary component and / or an inorganic auxiliary component, and if necessary, at least one biologically active auxiliary component are mixed with each other, and can be further made into molded bodies, granules, and powders. , film, felt and thread.

Description

technical field [0001] The present invention relates to the preparation and application of an antimicrobial preparation capable of delaying the release of active substances used in human medicine and veterinary medicine for treating local microbial infections of hard and soft tissues. Background technique [0002] In human and veterinary medicine, the treatment of local soft and hard tissue microbial infections requires high concentrations of topical antibiotics in the area of ​​infected tissue. It has long been known that the continuous use of antibiotics has its own set of problems. When continuous medication is used, it is often necessary to use a very high dose of antibiotics in order to achieve an effective antibacterial concentration of antibiotics in the infected tissue. Thus, especially in the case of aminoglycoside antibiotics and tetracycline antibiotics, their kidney and ear toxicity can seriously damage the body. Therefore, it is easy for people to think of loc...

Claims

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Application Information

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IPC IPC(8): A61K47/20A61J3/00A61K9/00A61K9/10A61K9/14A61K9/20A61K9/22A61K9/70A61K31/00A61K31/7036A61K31/726A61K45/08A61K47/02A61K47/06A61K47/12A61K47/14A61K47/16A61K47/24A61K47/32A61L27/54A61L31/16
CPCA61K9/0024A61K9/2013A61K9/204A61K31/00A61K31/7036A61L27/54A61L31/16A61L2300/406A61L2300/606A61P31/00A61P31/02A61P31/04
Inventor S·福哥特M·斯纳波劳KL-D·科恩
Owner HERAEUS KULZER
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