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Niclosamide colloidal suspension

A technology of niclosamide and gel suspension, which is applied in the field of new compositions of niclosamide, which can solve the problems of unsatisfactory drug efficacy, strong eye irritation, unfavorable environmental protection, etc., to reduce transdermal toxicity and save drugs Quantity, no explosion hazard effect

Inactive Publication Date: 2003-07-30
ZHUHAI QIAOJI OVERSEAS TRADE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because of the use of organic solvents in the processing of emulsifiable concentrates, it is not environmentally friendly and is highly irritating to the eyes; although wettable powders are better in environmental compatibility than emulsifiable concentrates, their efficacy is not ideal and the amount of use is large

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation Embodiment

[0011] Take 250 g / liter niclosamide gel suspension as an example:

[0012] Niclosamide 25 parts

[0013] 2 parts bentonite

[0014] Polyethylene glycol 1 part

[0015] Sorbitan stearate 15 parts

[0016] Alkylphenol polyoxyethylene (8) ether 2.5 parts

[0017] Sodium 3-oleamido-2-methoxybenzenesulfonate 2 parts

[0018] Ethylene glycol 0.5 parts

[0019] Polypropylene glyceryl ether 0.5 parts

[0020] 0.5 parts of benzoic acid

[0021] water make up 100 parts

[0022] 2. Examples of efficacy

[0023] Adopt following test method, have compared the concentrated suspending agent of the present invention, and the drug effect of conventional emulsifiable concentrate and wettable powder to snail. Breeding box: 40 cm × 25 cm × 20 cm (length × width × height), open, covered with gauze to prevent snails from climbing out. Breeding conditions: dark and humid environment. Place about 2 cm thick fine soil at the bottom of the box; temperature 27±2°C; humidity: 70-80% (soil

[...

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PUM

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Abstract

The present invention relates to niclosamide colloidal suspension and its preparation process. The niclosamide colloidal suspension is ropy fluid comprising solid niclosamide, water and several assistants. It is used for killing rice field snail, Fushou snail and schistosome. It has high pesticidal effect and is superior to oil emulsion, wettable powder and other conventional forms.

Description

[0001] The technical field of the present invention [0002] The present invention relates to a novel composition of niclosamide for use as a molluscicide. More specifically, the present invention relates to a niclosamide suspension. The above-mentioned colloidal suspension has good environmental compatibility, is used in an appropriate amount, and has better drug efficacy than conventional pesticide formulations. Background technique [0003] The chemical name of niclosamide is 2',5-dichloro-4'-nitrosalicylic acid aniline (2',5-dichloro-4'-nitrosalicylanilide). Niclosamide can be used as a molluscicide in agriculture, by killing its parasitic molluscs, such as snails, and snails are also used as agents for the prevention and treatment of schistosomiasis. There are mainly two dosage forms in the prior art: emulsifiable concentrate and wettable powder. Because of the use of organic solvents in the processing of em...

Claims

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Application Information

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IPC IPC(8): A01N25/04A01N37/22A01N37/48
Inventor 曹昌银
Owner ZHUHAI QIAOJI OVERSEAS TRADE CO LTD
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