Protective composite amino acid composition for kidney and its use

A composition, glycine technology, applied in the directions of drug combinations, peptide/protein components, urinary system diseases, etc., can solve the problem of the unexplained mechanism of amino acid protection, achieve increased glomerular filtration rate, reasonable combination mode, Protects the effect of oxidative phosphorylation

Inactive Publication Date: 2003-09-03
ZHEJIANG UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The mechanism of the protective effect of amino acids on renal function has not been elucidated

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Preparation of the composition of the present invention: weigh 5.5 grams of glycine, 7.5 grams of L-alanine, 0 grams of L-threonine, 7.5 grams of L-serine, 5 grams of L-valine, and 5 grams of L-leucine , 2 grams of L-isoleucine and 5 grams of L-proline were dissolved in 500 ml of 0.45% NaCl, and the pH value of the solution was adjusted to 6.5 with NaOH and HCl.

Embodiment 2

[0023] Protective effect of amino acid mixture on cisplatin-induced acute renal failure in rats

[0024] Experimental model: select male SD rats with a body weight of 250-350g, divide into 4 groups, control group (n=16): intravenous infusion of 0.9% sodium chloride 2ml, and then maintain the speed of 2ml / h; cisplatin group (n=12): After intravenous infusion of 0.9% sodium chloride 2ml, receive 10mg / kg cisplatin (10mg / ml), and continue intravenous infusion of sodium chloride solution at 2ml / h; cisplatin + amino acid group (n=10) intravenous infusion of 8 kinds of L-amino acids After 2ml of mixture, give 10mg / kg cisplatin, followed by amino acid 2ml / h; amino acid group (n=16): after intravenous infusion of 2ml of 8 kinds of L-amino acid mixture, maintain at 2ml / h. Anesthetized by intraperitoneal injection of pentobarbital sodium 60mg / kg, the body temperature was maintained at 37C. A dual-channel venous infusion set was inserted into the femoral vein on one side for liquid inject...

Embodiment 3

[0031] Protective effect of amino acid mixture on renal ischemia-reperfusion injury in rats.

[0032] 1. Preparation of the composition of the present invention: weigh 7.5 grams of glycine, 5.5 grams of L-alanine, 2.0 grams of L-threonine, 7.5 grams of L-serine, 5 grams of L-valine, and 5 grams of L-leucine 2 grams, 0 grams of L-isoleucine, and 6.5 grams of L-proline were dissolved in 500 ml of 0.45% NaCl, and the pH value of the solution was adjusted to 6.5 with NaOH and HCl.

[0033] 2. Experimental scheme Twenty-four healthy adult male Sprague-Dawley rats, weighing (230±18) g. Randomly divided into group A: sham operation group, group B: control group, group C: treatment group. 8 in each group. Anesthetized by intraperitoneal injection of 2% pentobarbital sodium 60mg / kg. The left femoral vein was intubated and connected to a micropump for continuous infusion of normal saline (groups A and B) or amino acid mixture (group C) at a fluid infusion rate of 1ml·100g -1 h -1. ...

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PUM

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Abstract

A compound amino acid composition for protecting the kidney contains glycine, alpha-alanine, threonine, serine, leucine, isoleucine, proline, etc, and can be used to prepare the medicine in the form injection, powder, tablet, or capsule for treating the acute renal dysfunction caused by cisplatin medicines and ischemia. Its advantage is high curative effect.

Description

technical field [0001] The invention relates to a novel compound amino acid composition, in particular to a kidney-protecting branched-chain amino acid composition, and the application of the composition in the pharmaceutical field for treating renal dysfunction. Background technique [0002] In clinical practice, acute renal dysfunction due to nephrotoxicity caused by inappropriate use of antibiotics, tumor chemotherapy drugs, contrast agents, etc. and sepsis is common in patients, as well as acute ischemic renal dysfunction due to trauma, shock, and major surgery. The renal excretion function of the patient decreases rapidly in a short period of time, the filtration function of the renal glomerulus drops below 50% of the normal value, the blood creatinine and blood urea nitrogen levels rise rapidly and cause water, electrolyte and acid-base balance disorders and symptoms of acute uremia . Although the incidence rate of acute renal failure is low, the case fatality rate is...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/195A61P13/12
Inventor 谢立平
Owner ZHEJIANG UNIV
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