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Application of scutellaria root extract in preparation of anti-stomach cancer medicine

A technology of Scutellaria baicalensis extract and gastric cancer, which is applied in the application field of Scutellaria baicalensis extract in the preparation of anti-gastric cancer drugs, can solve the problem that the anti-cancer mechanism of Scutellaria baicalensis extract is not clear, and achieves low cost, wide source and low toxicity. Effect

Inactive Publication Date: 2003-09-17
HANGZHOU HUADONG MEDICINE GRP PHARMA RES INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these studies are still in the very early stage, and the mechanism of anticancer effect of Scutellaria baicalensis extract is not clear yet.

Method used

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  • Application of scutellaria root extract in preparation of anti-stomach cancer medicine
  • Application of scutellaria root extract in preparation of anti-stomach cancer medicine
  • Application of scutellaria root extract in preparation of anti-stomach cancer medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] This example provides the extraction method of the Scutellaria baicalensis extract. First, decoct the Scutellaria baicalensis coarse powder twice, add acid to adjust the pH to 1-2, keep warm at 70-80°C, let stand for 12-24 hours, and filter. Stir the precipitate with water to form a suspension, adjust the pH to 7-7.5 with alkali to dissolve, add ethanol, stir, and filter. The filtrate is the Scutellaria baicalensis extract with effective Scutellaria baicalensis extract components.

Embodiment 2

[0055] What this embodiment provides is to use the existing commodity baicalin to prepare anti-gastric cancer drugs. Weigh 300 grams of baicalin (commercially available), 75 grams of mannitol, and 250 grams of sodium citrate, and use the conventional powder injection preparation process Make 1000 powder injections, each containing baicalin 300mg, as an anti-gastric cancer drug.

Embodiment 3

[0057] What this example provides is to obtain baicalein after hydrolyzing baicalin, weigh 100 grams of baicalein raw materials, add 66 g of lactose, 64 g of pregelatinized starch, 66 g of microcrystalline cellulose, and 3 g of magnesium stearate, and follow the conventional tableting process Prepare 1000 tablets, which is equivalent to 100 mg of baicalein per tablet, as an anti-gastric cancer drug. Example 4:

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Abstract

An application of the scutellaria extract in preparing the medicine for gastric cancer is disclosed, and it features that the scutellaria, scutellaroside, or their mixture can be used to prepare the pharmacologically receptable salt for suppressing the splitting of cancer cell, inducing the withering of cancer cell, and inhibiting the generation of blood vessel inside gastric cancer.

Description

technical field [0001] The invention relates to the use of the extract of Scutellaria baicalensis, in particular to the application of the extract of Scutellaria baicalensis in the preparation of anti-gastric cancer drugs. technical background [0002] The incidence of gastric cancer is declining year by year worldwide, but the death rate of gastric cancer is still the first in my country. According to incomplete statistics, gastric cancer death accounts for 2%-2.6% of the death of residents, and accounts for 2%-2.6% of the death of malignant tumors. 23%. Because chemotherapy is accompanied by great toxic and side effects, and gastric cancer is less sensitive to radiation, the application of radiotherapy in the treatment of gastric cancer is greatly limited. The treatment of gastric cancer is still dominated by surgery, chemotherapy and chemotherapy. Radiotherapy is only used as a means of adjuvant or palliative treatment. Although the treatment methods have been continuously ...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61P35/00
Inventor 刘新华潘福生胡祖耀
Owner HANGZHOU HUADONG MEDICINE GRP PHARMA RES INST
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