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Ferulic acid salt injection agent

A technology of ferulate and injection, applied in the field of new dosage forms of ferulate, can solve the problems of low bioavailability, slow efficacy and inability to take ferulate

Inactive Publication Date: 2003-09-17
成都世纪联合生物医药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The bioavailability of ferulate is not high, the drug is slow, and it should not be administered to patients who cannot swallow or are comatose

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0030] Preparation method of ferulate raw material

[0031] 1. Add 1-2 parts by weight of ferulic acid to ethanol and heat to dissolve. Take another 1 part by weight of piperazine or ligustrazine or ligustrazine and add ethanol to heat to dissolve, add this solution to the ferulic acid ethanol solution while it is hot, cool, filter, and wash with ethanol while stirring. Recrystallize with water or ethanol to obtain piperazine ferulic acid crystals or ligustrazine ferulic acid crystals or ligustrazine ferulic acid crystals, which are dried and crushed to obtain refined ferulic acid salt.

[0032] 2. Preparation method of ferulate injection

[0033] The preparation of ferulate raw material is the same as in Example 1.

[0034] Prescription 1

[0035] Piperazine ferulic acid 100g Tween 20 0.2g Water for injection 2000g

[0036] A total of 1000 bottles each containing 100mg of the main drug

[0037] Prescription 2

[0038] Ligustrazine ferulic acid 100g Tween 80 0.2g ethanol ...

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PUM

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Abstract

An injection of ferulates including piperazine ferulate, ligustrazine ferculate and ligustradole ferulate is prepared through dissolving ferulaic acid in alcohol while heating, dissolving one of the above mentioned ferulates in alcohol while heating, mixing them together while stirring, adding this solution to the alcoholic solution of ferulaic acid while hot, cooling, filtering, alcohol washing,recrystallizing in water or alcohol, and preparing injection. Its advantages are high biological utilization rate and quickly taking its effect.

Description

Technical field: [0001] The present invention is related to the new dosage form of ferulate, especially related to the injection of ferulate. technical background: [0002] Ferulic acid salt includes piperazine ferulic acid, ligustrazine ferulic acid, and ligustrazine ferulic acid. The three compounds are synthesized separately and are known to be used as active ingredients in the treatment of nephropathy. They are mainly used to treat various types of drugs. Glomerular diseases with microscopic hematuria and hypercoagulability, such as nephritis, chronic nephritis, early nephrotic syndrome, uremia, coronary heart disease, cerebral infarction, vasculitis, etc. The dosage form of the medicine for treating kidney disease made by ferulate is a tablet. The bioavailability of ferulic acid is not high, the drug effect is slow, and it should not be taken for patients who cannot swallow or are unconscious. Summary of the invention: [0003] The purpose of the present invention is to pro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/19A61K31/495A61P9/10A61P9/14A61P13/12
Inventor 陈耀明江云明新何以李顺兰
Owner 成都世纪联合生物医药有限公司