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Chloro-silicane polyethylene derivative, process for synthesizing and use thereof

A technology of polyethylene glycol and chlorosilane, which is applied in the direction of measuring devices, instruments, scientific instruments, etc., and can solve the problems of narrow application

Inactive Publication Date: 2003-12-31
INST OF MECHANICS - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Polyethylene glycol molecules modified by mercapto groups can only react with metal surfaces such as gold and silver, and the applicable surface is narrow

Method used

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  • Chloro-silicane polyethylene derivative, process for synthesizing and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 2

[0031] 3) Purify the product by distillation. Example 2 Cl 2 CH 3 Si(CH 2 ) 5 (OCH 2 CH 2 ) 50 OCH 2 CH 3 Synthesis

[0032] Step 1: Synthesis of CH 2 =CH(CH 2 ) 3 (OCH 2 CH 2 ) 50 OCH 3

[0033] 1) Mix 0.34ml 50% NaOH with 20.0g H(OCH 2 CH 2 ) 50 OCH 3 Mixing, electromagnetic stirring, 150 ° C oil bath for 30 minutes, with reflux nitrogen as the protective gas;

[0034] 2) Add 1.0 g of 5-bromo-1-ene-pentane to the above reaction system, stir it electromagnetically, and put it in an oil bath at 150°C for 16 hours;

[0035] 3) After the reactant was cooled, it was extracted 6 times with n-hexane, and the extracts were combined;

[0036] 4) concentrating the extract by rotary evaporation under reduced pressure to obtain a yellow oily substance containing monoether and diether;

[0037] 5) purify the product;

[0038] Step 2: Synthesis of Cl 2 CH 3 Si(CH 2 ) 5 (OCH 2 CH 2 ) 50 OCH 2 CH 3

[0039] 1) Add 4 equivalents of dichloromethylhydrosilane ...

Embodiment 3

[0041] 3) Purify the product by distillation. Example 3 Cl 3 Si(CH 2 ) 20 (OCH 2 CH 2 ) 4 OCH 3 Synthesis

[0042] Step 1: Synthesis of CH 2 =CH(CH 2 ) 18 (OCH 2 CH 2 ) 4 OCH 3

[0043] 1) Mix 0.34ml 50% NaOH with 5.0g H(OCH 2 CH 2 ) 4 OCH 3 Mixing, electromagnetic stirring, 120 ° C oil bath for 30 minutes, with reflux nitrogen as the protective gas;

[0044]2) Add 1.0 g of 20-bromo-1-ene-eicosane to the above reaction system, stir it electromagnetically, and place it in an oil bath at 120°C for 14 hours;

[0045] 3) After the reactant was cooled, it was extracted 6 times with n-hexane, and the extracts were combined;

[0046] 4) concentrating the extract by rotary evaporation under reduced pressure to obtain a yellow oily substance containing monoether and diether;

[0047] 5) purify the product;

[0048] Step 2: Synthesis of Cl 3 Si(CH 2 ) 20 (OCH 2 CH 2 ) 4 OCH 3

[0049] 1) Add 4 equivalents of trichlorosilane and 10 mg of benzoin dimethyl eth...

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PUM

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Abstract

The present invention relates to chlorsilane polyglycol derivative as one solid surface modifying compound. The derivative is prepared through condensation and addition reaction, and can inhibit the adsorption of protein molecule on the surface of solid. The derivative is suitable for application in biomedicine field.

Description

technical field [0001] The invention relates to a surface modification compound, in particular to a class of modified solid surface, a compound for inhibiting the adsorption of biomolecules on the solid surface, and a synthesis method and application thereof. Background technique [0002] Polyethylene glycol molecules have good biocompatibility and have been widely used in the biological field, especially for surface modification of materials. The two ends of the polyethylene glycol molecule are hydroxyl groups, which are not easy to chemically react with the solid surface to achieve the purpose of surface modification. Therefore, it is common practice to modify the end groups of the polyethylene glycol molecules so that the modified end groups Clusters readily react with solid surfaces. A research team at Harvard University (Joydeep Lahiri, Lyle Isaacs, Joe tien, George M. Whitesides, Analytical Chemistry, 1999, 71, 777-790) used sulfhydryl groups to modify the end gro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G65/48G01N33/545
Inventor 王战会靳刚
Owner INST OF MECHANICS - CHINESE ACAD OF SCI