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Vanillic aldehyde drip pill and its preparation method

A technology of aldehyde dropping pills and vanillin, which is applied in the fields of pill delivery, active ingredients of aldehydes, nervous system diseases, etc. It can solve the problems of low dissolution rate and dissolution rate, long disintegration time of vanillin tablets, and affecting the therapeutic effect of vanillin, etc. problem, to achieve the effect of improved dissolution rate and dissolution rate, convenient carrying and taking, and small pill volume

Inactive Publication Date: 2004-05-05
HONGYI SCI & TECH CO LTD NANCHANG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Vanillin has aroma, is unstable to light, is slightly soluble in water, takes a long time to disintegrate in vanillin tablets, has low dissolution rate and dissolution rate, poor absorption, low bioavailability, and a large amount of excipients. Children, the elderly, Bedridden patients and patients with dysphagia are inconvenient to take and have poor compliance, which affects the therapeutic effect of vanillin

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0051] prescription:

[0052] Vanillin 5g

[0053] Polyethylene glycol 6000 15g

[0054] Made into 1000 tablets

[0055] Preparation method: Take the superfinely pulverized vanillin powder that has passed through a 200-mesh sieve and add it to the molten polyethylene glycol 6000 matrix, stir evenly, use dimethyl silicone oil as the coolant, make pellets by the dripping method, and dry, and get ready.

example 2

[0057] prescription:

[0058] Vanillin 5g

[0059] Polyethylene glycol 4000 15g

[0060] Made into 1000 tablets

[0061] Preparation method: Take the superfinely pulverized vanillin powder that has passed through a 200-mesh sieve and add it to the molten polyethylene glycol 4000 matrix, stir evenly, use dimethyl silicone oil as a coolant, make pellets by dripping method, and dry, and then get it.

example 3

[0063] prescription:

[0064] Vanillin 5g

[0065] Polyethylene glycol 6000 5g

[0066] Polyethylene glycol 4000 10g

[0067] Made into 1000 tablets

[0068] Preparation method: Take the vanillin powder that has been superfinely pulverized and passed through a 200-mesh sieve, add it to the molten polyethylene glycol 4000 and polyethylene glycol 6000 mixed matrix, stir it evenly, use dimethyl silicone oil as the coolant, and prepare by dripping method Pills, dry, and get ready.

[0069] Four, example 4

[0070] prescription:

[0071] Vanillin 5g

[0072]Glyceryl monostearate 15g

[0073] Made into 1000 tablets

[0074] Preparation method: Take the superfinely crushed vanillin powder that has passed through a 200-mesh sieve, add it to the molten glyceryl monostearate matrix, mix well, use ice water as a coolant, make pellets by dripping method, and dry, and get ready.

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PUM

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Abstract

A dripping pill of vanillic aldehyde and its preparing process are disclosed. Its advantages are high dissolving and disintegrating speed, high stripping percentage, quickly taking its curative effect, and low cost.

Description

Technical field [0001] The invention relates to a medical preparation and a preparation method thereof, in particular to vanillin dripping pills and a preparation method thereof. Background technique [0002] Animal experiments have confirmed that vanillin can significantly reduce the spontaneous activities of mice and prolong the hypnotic time of cyclohexene barbital sodium. It can fight against convulsions caused by pentetrazole in mice, but has no effect on convulsions caused by electric shock in mice; It can resist the brain waves of epilepsy induced by pentetrazole in rabbits. [0003] Vanillin is mainly absorbed through the intestinal tract, with an absorption rate of over 98% and a serum protein binding rate of 71%±1%. It easily passes through the blood-brain barrier and is mainly excreted through the kidneys. It is clinically used for minor epilepsy and auxiliary medication for various types of epilepsy. Only vanillin tablets are currently on the market. [0004] Vanillin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/11A61P25/08
Inventor 钱进许军彭红李平刘孝乐
Owner HONGYI SCI & TECH CO LTD NANCHANG