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Cucurbitacin drop pill and preparing method thereof

A technology of cucurbitacin and dripping method, which is applied in the field of cucurbitacin dripping pills and its preparation, can solve the problems of affecting the therapeutic effect of cucurbitacin, long disintegration time of cucurbitacin tablets, large proportion of auxiliary materials, etc., and achieves convenience in carrying and taking , The effect of small pill volume and reduced dosage of excipients

Inactive Publication Date: 2004-09-15
HONGYI SCI & TECH CO LTD NANCHANG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Cucurbitacin tablets take a long time to disintegrate, have poor absorption, low bioavailability, and a large proportion of excipients. Children, the elderly, bedridden patients, and patients with dysphagia are inconvenient to take and have poor compliance, which affects the therapeutic effect of cucurbitacin.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0020] prescription:

[0021] Cucurbitacin 0.1g

[0022] Macrogol 6000 20g

[0023] Makes 1000 capsules

[0024] Preparation method: Take cucurbitacin fine powder that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to molten polyethylene glycol 6000 matrix, stir well, use simethicone oil as coolant, make pellets by dropping, dry, and obtain.

example 2

[0026] prescription:

[0027] Cucurbitacin 0.1g

[0028] Macrogol 4000 20g

[0029] Makes 1000 capsules

[0030] Preparation method: Take cucurbitacin powder that has been superfinely pulverized and passed through a 200-mesh sieve, add it to molten polyethylene glycol 4000 matrix, stir well, use simethicone oil as coolant, make pellets by drop method, dry, and obtain.

example 3

[0032] prescription:

[0033] Cucurbitacin 0.1g

[0034] Macrogol 6000 10g

[0035] Macrogol 4000 10g

[0036] Makes 1000 capsules

[0037] Preparation method: Take the cucurbitacin fine powder that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten polyethylene glycol 4000 and polyethylene glycol 6000 mixed matrix, stir well, use simethicone oil as the coolant, and drop the method Pills, dried, ready to use.

[0038] 4. Example 4

[0039] prescription:

[0040] Cucurbitacin 0.1g

[0041] Glyceryl monostearate 20g

[0042] Makes 1000 capsules

[0043] Preparation method: Take the cucurbitacin fine powder that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten glyceryl monostearate matrix, mix well, use ice water as the cooling agent, make pellets by drop method, and dry to obtain.

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PUM

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Abstract

The present invention utilizes ultramicropulverization and dripping pill preparation production process to make cucurbitacin dripping pills, and can attain the goal of raising disintegration and dissolution speed, quickly obtaining therapeutic effect, raising stability of medicine, reducing dose of auxiliary material, reducing production cost and convenient administration. Said pill not only can be sucked, but also can be swallowed.

Description

technical field [0001] The invention relates to a medicine preparation and a preparation method thereof, in particular to cucurbitacin dripping pills and a preparation method thereof. Background technique [0002] Cucurbitacin has the functions of detoxifying, clearing away heat, promoting dampness and reducing jaundice. It is used as an adjuvant therapy for persistent hepatitis, chronic hepatitis and primary liver cancer caused by damp heat and toxin. [0003] The disintegration time of cucurbitacin tablets is long, the absorption is poor, the bioavailability is low, and the proportion of excipients is large. Children, the elderly, bedridden patients and patients with dysphagia are inconvenient to take and have poor compliance, which affects the therapeutic effect of cucurbitacin. [0004] The present invention is to make cucurbitacin drop pills by applying ultrafine pulverization technology and drop pill preparation technology, thereby overcoming the above defects of cucu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/57A61P1/16A61P31/12
Inventor 钱进许军彭红李平朱丹刘孝乐
Owner HONGYI SCI & TECH CO LTD NANCHANG
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