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Slowly-released traditional Chinese medicine adhering tablet for treating mouth mucous diseases and its prepn. method

An oral mucosa and drug technology, applied in the field of sustained-release oral adhesive tablets, can solve the problems of patient's oral discomfort, saliva flushing, short action time, etc., and achieve the effects of prolonging treatment time, convenient use and moderate size

Inactive Publication Date: 2004-10-20
CHINA PHARM UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because dexamethasone is a hormone drug, it has relatively large side effects and cannot be used in large doses for a long time.
For a long time, traditional Chinese medicine treatment has been sprayed into the mouth by powder or powder. The medicine sprayed on the mucous membrane is easily washed away by saliva, and the action time is short. At the same time, the patient feels uncomfortable in the mouth and it is difficult to achieve the desired effect
Although the polymer film can preliminarily solve the problem of short action time and overcome the shortcomings of poor adhesion of powder or powder, but because the film melts quickly when it meets saliva, the drug action time is not ideal and the drug loading of the film is limited, especially For traditional Chinese medicine compound treatment, the dosage is too small to achieve the desired therapeutic effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0152] Raw materials: Qingdai 120g, catechu 40g, borneol 40g, licorice 80g, Radix Ophiopogon japonicus 80g, Scrophulariaceae 80g, appropriate amount of peppermint oil.

[0153] Preparation excipients: CaSO 4 33.3g, NaHCO 3 33.3g, microcrystalline cellulose (microcrystalline cellulose) 150g, Carbopol 934p 28.6g, hydroxypropyl methylcellulose (K100M) 15.4g, appropriate amount of magnesium stearate.

[0154] A total of 1000 oral adhesive tablets were prepared. Clinically, it has the effects of clearing away heat and expeling fire, cooling blood and removing rot, nourishing yin and promoting muscle growth, and is mainly used for the treatment of recurrent oral ulcers. Adults and children over 12 years old take 2-3 tablets each time, 2 times a day, and increase to 3 times a day, 2-3 tablets each time for acute attack and severe disease.

[0155] Weigh licorice, Ophiopogon japonicus and Scrophulariaceae according to the prescription, soak in 10 times the amount of water, and de...

Embodiment 2

[0164] Raw materials: Qingdai 200g, catechu 50g, borneol 50g, licorice 100g, Radix Ophiopogon japonicus 100g, Scrophulariaceae 100g, appropriate amount of peppermint oil.

[0165] Preparation excipients: CaSO 4 30.3g, NaHCO 3 20.3g, 130g of microcrystalline cellulose, 36.6g of hydroxypropyl cellulose, 18.4g of sodium carboxymethyl cellulose, appropriate amount of magnesium stearate.

[0166] Licorice root, Ophiopogon japonicus, Radix Scrophulariae extract after water decoction and alcohol precipitation, add calcium sulfate, add indigo naturalis, catechu to make medicinal powder; medicinal powder add microcrystalline cellulose, sodium bicarbonate, bioadhesive material hydroxypropyl cellulose and After sodium carboxymethyl cellulose, granulate; after adding borneol and peppermint oil, add stearic acid, and compress into tablets.

[0167]Detailed preparation and assay methods are the same as in Example 1. Conform to the relevant provisions of the Chinese Pharmacopoeia 2000 e...

Embodiment 3

[0169] Raw materials: Qingdai 400g, catechu 150g, borneol 150g, licorice 300g, Radix Ophiopogon japonicus 300g, Scrophulariaceae 300g, appropriate amount of peppermint oil.

[0170] Preparation excipients: CaSO 4 35.3g, NaHCO 3 28.3g, microcrystalline cellulose 165g, Carbopol 934p 34.6g, hydroxypropyl methylcellulose (K15M) 15.4g, appropriate amount of magnesium stearate.

[0171] Licorice root, Ophiopogon japonicus, Scrophulariaceae extract after water decoction and alcohol precipitation, add calcium sulfate, Qingdai, catechu to make medicine powder; medicine powder add microcrystalline cellulose, sodium bicarbonate, bioadhesive materials Carbopol 934p and hydroxypropyl After adding methyl cellulose, granulate; after adding borneol and peppermint oil, add stearic acid, and compress into tablets.

[0172] Detailed preparation and assay methods are the same as in Example 1. Conform to the relevant provisions of the Chinese Pharmacopoeia 2000 edition, an appendix IL tablet ...

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PUM

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Abstract

A Chinese medicine in the form of slow-releasing oral adhesive tablet for treating mouth mucosa disease is prepared from 7 Chinese-medicinal materials including natural indigo, catechu, borneol, liquorice root, etc. Its advantages are high curative effect and low toxic by-effect.

Description

technical field [0001] The invention belongs to a slow-release oral adhesive tablet containing an effective part of a traditional Chinese medicine compound for treating oral mucosal diseases and a preparation method thereof. Background technique [0002] Oral ulcer is a common oral mucosal disease, frequently-occurring, and has the characteristics of periodic and burning pain. Once an ulcer is formed locally, it can be secondary infected, causing inflammation and necrosis of the local tissue of the ulcer, prolonging the course of the disease and increasing pain. It is also one of the difficult and miscellaneous diseases in the Department of Stomatology. Modern medicine thinks that its pathogenesis is relatively complicated, and antibiotics, vitamins, painkillers and other symptomatic treatment methods are the first choice for treatment, but the curative effect is not good, and there is no ideal treatment method at present. In recent years, the developed dexamethasone double...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61P1/02
Inventor 王广基朱萱萱刘建平赵陆华
Owner CHINA PHARM UNIV
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