Slowly-released traditional Chinese medicine adhering tablet for treating mouth mucous diseases and its prepn. method

An oral mucosa and drug technology, applied in the field of sustained-release oral adhesive tablets, can solve the problems of patient's oral discomfort, saliva flushing, short action time, etc., and achieve the effects of prolonging treatment time, convenient use and moderate size

Inactive Publication Date: 2004-10-20
CHINA PHARM UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because dexamethasone is a hormone drug, it has relatively large side effects and cannot be used in large doses for a long time.
For a long time, traditional Chinese medicine treatment has been sprayed into the mouth by powder or powder. The medicine sprayed on the mucous membrane is easily washed away by saliva, and the action time is short. At the same time, the patient feels uncomfortable in the mouth and it is difficult to ac

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0151] Example 1:

[0152] Raw materials: Indigo Naturalis 120g, catechu 40g, borneol 40g, licorice 80g, Ophiopogon japonicus 80g, Scrophulariaceae 80g, peppermint oil appropriate amount.

[0153] Preparation excipients: CaSO 4 33.3g, NaHCO 3 33.3g, 150g of microcrystalline cellulose (microcrystalline cellulose), 28.6g of Carbopol 934p, 15.4g of hydroxypropyl methylcellulose (K100M), appropriate amount of magnesium stearate.

[0154] A total of 1,000 oral adhesive tablets were produced. Clinically, it has the effects of clearing away heat, cooling blood and removing rot, nourishing yin and promoting muscle. It is mainly used for the treatment of recurrent oral ulcers. Adults and children over 12 years old 2 times a day, 2-3 tablets each time, for acute attacks and severe illness, it can be increased to 3 times a day, 2-3 tablets each time.

[0155] According to the prescription, weigh licorice, Ophiopogon japonicus and Xuan, soak in 10 times the amount of water, and decoct 3 times...

Example Embodiment

[0163] Example 2:

[0164] Raw materials: 200g Indigo Naturalis, 50g catechu, 50g borneol, 100g licorice, 100g Ophiopogon japonicus, 100g Scrophulariaceae, appropriate amount of peppermint oil.

[0165] Preparation excipients: CaSO 4 30.3g, NaHCO 3 20.3g, 130g of microcrystalline cellulose, 36.6g of hydroxypropyl cellulose, 18.4g of sodium carboxymethylcellulose, appropriate amount of magnesium stearate.

[0166] The extract of licorice, Ophiopogon japonicus and Scrophulariaceae after decocting and alcohol precipitation, adding calcium sulfate, adding Indigo Naturalis and catechu to make medicinal powder; medicinal powder adding microcrystalline cellulose, sodium bicarbonate, bioadhesive material hydroxypropyl cellulose and After carboxymethyl cellulose sodium, granulate; add borneol and peppermint oil, add stearic acid, and press tablets.

[0167]The detailed preparation and measurement methods are the same as in Example 1. It complies with the relevant regulations of IL tablets ...

Example Embodiment

[0168] Example 3:

[0169] Raw materials: Indigo Naturalis 400g, catechu 150g, borneol 150g, licorice 300g, Ophiopogon japonicus 300g, Scrophulariaceae 300g, peppermint oil.

[0170] Preparation excipients: CaSO 4 35.3g, NaHCO 3 28.3g, microcrystalline cellulose 165g, carbopol 934p 34.6g, hydroxypropyl methyl cellulose (K15M) 15.4g, appropriate amount of magnesium stearate.

[0171] The extract of licorice, Ophiopogon japonicus and Scrophulariaceae after decocting and alcohol precipitation, adding calcium sulfate, Indigo Naturalis, and catechu to make medicinal powder; medicinal powder adding microcrystalline cellulose, sodium bicarbonate, bioadhesive material Carbopol 934p and hydroxypropyl After base methyl cellulose is granulated; after adding borneol and peppermint oil, stearic acid is added, and the tablet is compressed.

[0172] The detailed preparation and measurement methods are the same as in Example 1. It complies with the relevant regulations of IL tablets in an appendi...

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Abstract

A Chinese medicine in the form of slow-releasing oral adhesive tablet for treating mouth mucosa disease is prepared from 7 Chinese-medicinal materials including natural indigo, catechu, borneol, liquorice root, etc. Its advantages are high curative effect and low toxic by-effect.

Description

technical field [0001] The invention belongs to a slow-release oral adhesive tablet containing an effective part of a traditional Chinese medicine compound for treating oral mucosal diseases and a preparation method thereof. Background technique [0002] Oral ulcer is a common oral mucosal disease, frequently-occurring, and has the characteristics of periodic and burning pain. Once an ulcer is formed locally, it can be secondary infected, causing inflammation and necrosis of the local tissue of the ulcer, prolonging the course of the disease and increasing pain. It is also one of the difficult and miscellaneous diseases in the Department of Stomatology. Modern medicine thinks that its pathogenesis is relatively complicated, and antibiotics, vitamins, painkillers and other symptomatic treatment methods are the first choice for treatment, but the curative effect is not good, and there is no ideal treatment method at present. In recent years, the developed dexamethasone double...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61P1/02
Inventor 王广基朱萱萱刘建平赵陆华
Owner CHINA PHARM UNIV
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