Use of insulin promoting peptide and nutrient, parenteral nutrition composition and pharmaceuticals

An insulin-stimulating peptide and nutritional composition technology, applied in the directions of drug combination, drug delivery, carbohydrate active ingredients, etc., can solve the problems of prolonging the healing time, and achieve the effect of stable blood sugar level and satisfying calorie deficiency.

Inactive Publication Date: 2004-11-03
AMYLIN PHARMA INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

If the patient does not receive proper nutrition, as is often the case with traditional parenteral nutrition, healing times are prolonged and ancillary problems related to the patient's initial malnutrition state frequently occur

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0049] A 60-year-old patient weighing 75 kg received parenteral feeding for inflammatory bowel disease. Parenteral nutrition was supplied through a central venous catheter through an infusomate containing 1.5 liters of 40% glucose solution, about 600 g of glucose in 24 hours, and 1 liter of 10% commercial amino acid mixture. Blood glucose values ​​of 160-190 mg / dl were obtained without GLP-1(7-36)amide. GLP-1(7-36)amide was then administered, and blood glucose levels dropped to about 100 mg / dl even though the high rate of glucose administration to the patient was continued.

[0050] GLP-1 or GIP can be used as a matching drug. Insulinotropic peptide agents were prepared by diluting stock solutions of the following peptides 20:1 with normal saline. A stock solution of GLP-1 was prepared containing 50 μg / ml dissolved in 0.9% NaCl plus human serum albumin (final concentration 1% vol / vol). The solution is tested for bacterial contamination and pyrogens and can be stored for 3 m...

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PUM

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Abstract

A composition and method for improved administration of nutrients is described. The method includes co- or separate administration of a source of nutrients, especially carbohydrates, and insulintropic peptides and derivatives, analogs, fragments and the like. The method and composition provide high carbohydrate nutrition while avoiding hyper- and hypoglycemia and their attendant deleterious effects.

Description

[0001] This application is a divisional application of the application dated August 22, 1996, application number 96196938.5, and invention titled "Method and Composition for Enhancing Parenteral Nutrition". technical field [0002] The present invention relates to the field of parenteral nutrition. Background technique [0003] Patients suffering from a variety of diseases often require nutritional intake through routes other than the digestive tract. Patients requiring surgery, comatose patients, patients with digestive disorders, stroke patients and patients in the process of healing often receive parenterally administered carbohydrates and concomitant lipids, electrolytes, minerals, vitamins and amino acids in various combinations. Administration is typically done by intravenous injection or infusion, although it can be subcutaneous, intramuscular, peritoneal, or other methods. [0004] Health care professionals should take c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A23L33/18A61K9/22A61K31/00A61K31/70A61K31/7004A61K38/00A61K38/22A61K38/26A61P3/00A61P3/02A61P3/08
CPCA23L1/3053A61K38/26A61K38/22A23L33/18A61P3/00A61P3/02A61P3/10A61P3/08A61K2300/00
Inventor M·A·纳克F·W·瓦格纳
Owner AMYLIN PHARMA INC
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