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Pig immunoglobulin contained oral medicine

A technology of immunoglobulin and pharmaceutical preparations, which is applied in the field of oral pharmaceutical preparations, can solve the problems that there are no research reports on porcine serum immunoglobulins, and achieve the effects of preventing host cell adhesion, low cost, and good therapeutic effect

Inactive Publication Date: 2004-11-10
YICHUN ENG MACHINERY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far there is no research report on porcine serum immunoglobulin

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Embodiment 1, preparation of oral pharmaceutical preparation Y-1 of the present invention

[0029]Centrifuge 10,000 g of fresh pig blood at 3,000 rpm for 30 minutes at 2°C, and collect about 4,500 g of serum; add water for injection with a serum volume of 30v% to the obtained serum in sequence, and 1% of serum volume and 30v% of serum volume. Fano solution, 0.01v% caprylic acid in serum volume, stir the mixed solution evenly, let it stand for 5 minutes, remove the supernatant; centrifuge the obtained supernatant at 2°C at a speed of 3000rpm for 30 minutes, remove the precipitate; supernatant Add activated carbon of 0.01wt% supernatant to the liquid, stir evenly, and filter; the filtrate is concentrated by ultrafiltration with an 80K ultrafiltration membrane to a protein concentration of 2.0g / 100ml, and heated in a water bath at 40°C for 15 hours; The solution is wrapped in a 100K ultrafiltration membrane and then concentrated by ultrafiltration. After sterilizing and fi...

Embodiment 2

[0030] Embodiment 2, preparation of oral pharmaceutical preparation Y-2 of the present invention

[0031] Centrifuge 10,000 g of fresh pig blood at 6,000 rpm for 5 minutes at 8° C., and collect about 4,600 g of serum; add water for injection with a serum volume of 100 v% to the obtained serum in sequence, and 100 v% of serum volume, and 10% of the serum volume. Fano solution, 0.5v% octanoic acid in serum volume, stir the mixed solution evenly, let it stand for 30 minutes, remove the supernatant; centrifuge the obtained supernatant at 8°C at a speed of 6000rpm for 5 minutes, remove the precipitate; supernatant Add 0.1wt% activated carbon of the supernatant to the liquid, stir evenly, and filter; the filtrate is concentrated by ultrafiltration with a 50K ultrafiltration membrane to a protein concentration of 4.0g / 100ml, and heated in a water bath at 70°C for 6 hours; The solution was wrapped in a 100K ultrafiltration membrane and then concentrated by ultrafiltration. After steri...

Embodiment 3

[0032] Embodiment 3, preparation of oral pharmaceutical preparation Y-3 of the present invention

[0033] Centrifuge 10,000 g of fresh pig blood at 4,500 rpm for 20 minutes at 6° C., and collect about 4,400 g of serum; add water for injection with a serum volume of 60 v% to the obtained serum in sequence, and a serum volume of 60 v %, and a concentration of 5% diuretic. Fano solution, 0.2v% octanoic acid in serum volume, stir the mixed solution evenly, let it stand for 15 minutes, remove the supernatant; centrifuge the obtained supernatant at 6°C at a speed of 4500rpm for 15 minutes, remove the precipitate; supernatant Add activated carbon of 0.05wt% supernatant to the liquid, stir evenly, and filter; the filtrate is concentrated by ultrafiltration with a 100K ultrafiltration membrane to a protein concentration of 3.0g / 100ml, and heated in a water bath at 60°C for 10 hours; The solution is wrapped in an 80K ultrafiltration membrane and then concentrated by ultrafiltration. Aft...

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PUM

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Abstract

The invention relates to an oral medication preparation for the prevention and treatment of diseases of digestive canal infection containing pig IgE, wherein the IgE is isolated from the pig serum with biological activity. The process for isolation comprises separating serum from pig blood, removing the impure protein in the serum, removing the micromolecular impurity substance through concentration and carrying out virus deactivation. The oral medication preparation provided by the invention can also contain the pharmaceutically acceptable findings.

Description

technical field [0001] The invention relates to an oral pharmaceutical preparation, especially an oral pharmaceutical preparation for preventing and treating viral or / and bacterial infectious diseases. technical background [0002] Viral and / or bacterial infectious diseases are generally treated with antibiotic drugs, which are prone to drug resistance, and some drugs, such as penicillin, are easy to cause allergies to some people, and severe cases may be fatal. [0003] As early as the 18th century, it was discovered that breastfed infants had stronger resistance to diseases such as the gastrointestinal tract than artificially fed infants. At the beginning of the 20th century, further research explained this phenomenon as breast milk is rich in immunoglobulin (Immunoglobulin, Ig for short), which contains IgA and a small amount of IgM. Because both IgA and IgM have J chains, they can accept secretory sheets, which are synthesized by mucosal epithelial cells, can protect gl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/395A61P31/04A61P31/12C07K16/18
Inventor 杜心江
Owner YICHUN ENG MACHINERY
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