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Beta-adrenergic blockade reversal of catabolism after severe burn

A technique for epinephrine and severe burns, applied in the field of beta-adrenergic antagonists, treating individuals with severe burns, and can solve the problem that there is no effective method for reducing the catabolism of muscle protein in burn patients.

Inactive Publication Date: 2004-11-24
RES DEVMENT FOUND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] A deficiency of the prior art is that there is no effective method for reducing muscle protein catabolism in burn patients

Method used

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  • Beta-adrenergic blockade reversal of catabolism after severe burn
  • Beta-adrenergic blockade reversal of catabolism after severe burn
  • Beta-adrenergic blockade reversal of catabolism after severe burn

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] subjects

[0026] The study was approved by The University of Texas Medical Branch Institutional Review Board, and written informed consent was obtained from each patient's guardian. Inclusion criteria were: children under 18 years of age with burns greater than 40% total surface area (TBSA) and transferred to hospital within one week of injury. Patients with a known history of asthma were excluded.

[0027] Within 48 hours of admission, each patient's burnt portion was excised and autograft and allograft skin were transplanted. The patient is returned to the operating room after the autograft donor site has healed (6-10 days). The grafting procedure then continues in stages until the wound is closed.

[0028] Individual patients received nutrition containing Vivonex TEN (Sandoz Nutritionals, Minneapolis, MN) via a naso-duodenal tube. Deliver the daily calorie intake at a calculated rate of 1500 kcal per square meter of total surface area burned + 1500 kcal per sq...

Embodiment 2

[0030] Research design

[0031] From January 1999 to December 1999, 25 subjects underwent a forward randomized trial. Thirteen of them received propranolol and the other 12 served as untreated controls. Group with random number table.

[0032]After the first surgery, metabolic tests were performed on all subjects on day 5 after surgery. Resting energy expenditure (REE) and net protein balance of legs were measured as primary output variables. In addition, baseline total body potassium scans were performed on all subjects to determine fat-free body mass. After the second surgery, propranolol subjects started oral propranolol at a dose of 0.33 mg / kg every 4 hours (1.98 mg / kg / day). This dose was adjusted to reduce the subject's heart rate by 25% compared to the patient's 24-hour average heart rate before drug treatment. Heart rate and blood pressure were monitored continuously during the study. Maintain and / or reduce propranolol dose when blood pressure is below the mean ...

Embodiment 3

[0035] vital signs

[0036] Temperature, heart rate, systolic and diastolic blood pressure were measured hourly by standard continuous bladder temperature monitor, ECG monitor, and arterial catheter. The mean values ​​for each 24-hour period were determined for each patient. Heart rates were compared between groups during the study. Additional analyzes were performed between groups on the day of the stable isotope study or varied by treatment.

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Abstract

Provided herein is a method of method of treating an individual having a severe burn, comprising the step of administering to said individual a pharmacologically effective dose of a beta-adrenergic antagonist.

Description

Background of the invention [0001] Federal Funding Statement [0002] This invention was made in part with funding from the National Institutes of Health. Accordingly, the Federal Government has certain rights in this invention. [0003] Background of the invention [0004] The present invention relates generally to the field of burn patient treatment. More specifically, the present invention relates to a method of reversing catabolism by blocking beta-adrenergic after severe burn injury. [0005] Description of related technologies [0006] The hypermetabolic response to severe burns is associated with increased energy expenditure and substrate release from protein and fat stores. After major trauma, net protein catabolism increases, which leads to loss of muscle mass and muscle wasting 1，2 . and muscle proteolysis in severe burns 3 This delays patient recovery while increasing morbidity and mortality 4 . [0007] Endogenous catecholamines are major mediators o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/00A61K31/135A61K45/00A61K31/138A61K31/352A61K31/407A61K31/5377A61P17/02
CPCA61K31/135A61K31/00Y10S424/81A61P17/02A61P39/00
Inventor D·N·赫恩东
Owner RES DEVMENT FOUND