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Qingkailing oral disintegration tablet and its preparing method

A technology of orally disintegrating tablets and compound disintegrants, which is applied in the field of Qingkailing orally disintegrating tablets and its preparation, can solve the problems of onset speed, storage and transportation, limitations of dosage forms, waste of resources, etc. , to achieve the effect of good pharmacological effect, rapid onset and rapid disintegration

Inactive Publication Date: 2005-03-02
张晴龙
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In clinical application, Qingkailing injection has played a very good role in relieving and treating patients' pain, and the application volume is very large. However, in the production process, due to the strict requirements for the preparation of injection preparations, the finished product of Qingkailing injection is qualified. The rate can only reach about 70%, wasting huge resources; although Qingkailing effervescent tablets solve the problem of wasting resources, but limited by the dosage form, there is no good solution in terms of onset speed, storage and transportation. Therefore, inventing a Qingkailing preparation that has the characteristics of injections, can solve the problem of waste of resources, and is easy to store and transport will make a huge contribution to society

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0127] (1) bulk drug of the present invention is:

[0128] 6 grams of cholic acid, 90 grams of mother-of-pearl powder, 7 grams of hyodeoxycholic acid, 40 grams of gardenia, 40 grams of buffalo horn powder, 350 grams of isatidis, 9 grams of baicalin, and 9 grams of honeysuckle extract;

[0129] (2) Take gardenia and Radix Radix and add 4 times of water, extract 2 times, each time for 2 hours, filter, combine the extracts, concentrate to a solution with a relative density of 1.05 at 50°C, add ethanol to make the solution alcohol content 40 %, stand still for 24 hours, filter, take the supernatant, recycle the ethanol to the utmost, vacuum concentrate, dry to obtain gardenia and isatidis extracts;

[0130] (3) Take mother-of-pearl powder and buffalo horn powder, add 10 times of water to decoct twice, each time for 2 hours, filter, combine the filtrate, filter residue hydrolyzed with 2mol / l sulfuric acid for 6 hours, filter, and filtrate with calcium hydroxide Adjust the pH value...

Embodiment 2

[0134] (1) bulk drug of the present invention is:

[0135] Cholic acid 7g, mother-of-pearl powder 110g, hyodeoxycholic acid 8g, gardenia 60g, buffalo horn powder 60g, isatidis 450g, baicalin 11g, honeysuckle extract 11g;

[0136] (2) Take gardenia and Radix Radix and add 8 times of water, extract 5 times, each time for 4 hours, filter, combine the extracts, concentrate to a solution with a relative density of 1.10 at 50°C, add ethanol to make the solution alcohol content 60 %, stand still for 24 hours, filter, take the supernatant, recycle the ethanol to the utmost, vacuum concentrate, dry to obtain gardenia and isatidis extracts;

[0137] (3) Take mother-of-pearl powder and buffalo horn powder, add 20 times of water and decoct 4 times, each time for 4 hours, filter, combine the filtrate, filter residue hydrolyze with 2mol / l sulfuric acid for 10 hours, filter, filtrate with calcium hydroxide Adjust the pH value to 6, filter, combine the filtrate with the above-mentioned water...

Embodiment 3

[0141] (1) bulk drug of the present invention is:

[0142] Cholic acid 6.5g, mother-of-pearl powder 100g, hyodeoxycholic acid 7.5g, gardenia 50g, buffalo horn powder 50g, isatidis 400g, baicalin 10g, honeysuckle extract 10g;

[0143] (2) Take gardenia and Radix Radix and add 5 times of water, extract 3 times, each time for 3 hours, filter, combine the extracts, concentrate to a solution with a relative density of 1.06 at 50°C, add ethanol to make the solution alcohol content 45 %, stand still for 24 hours, filter, take the supernatant, recycle the ethanol to the utmost, vacuum concentrate, dry to obtain gardenia and isatidis extracts;

[0144] (3) Take mother-of-pearl powder and buffalo horn powder, add 12 times of water and decoct 3 times, each time for 3 hours, filter, combine the filtrate, filter residue hydrolyze with 2mol / l sulfuric acid for 7 hours, filter, and filtrate with calcium hydroxide Adjust the pH value to 5, filter, combine the filtrate with the above-mentioned ...

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Abstract

The present invention discloses Qingkailing oral disintegration tablet and its preparation process. The present invention features that the extracted effective parts of Chinese medicinal materials cape jasmine, isatis root, nacre and buffalo horn are mixed with cholic acid, hyodeoxycholic acid, baicalin, honeysuckle extract and medicinal supplementary material to compound the medicine. The present invention features its composite disintegrating agent, which consists of erythritol and chitin, substituted hydroxypropyl methyl cellulose, carboxymethyl starch sodium, cross-linked carboxymethyl starch sodium or insoluble cross-linked polyvinyl pyrrolidone in certain proportion. The erythritol has also the effect of corrective, and this can reduce the amount of the medicinal supplementary material. Pharmaceutical experiment shows that the Qingkailing oral disintegration tablet has fast disintegration speed, fast acting and high pharmacological effect.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine pharmacy, and in particular relates to a Qingkailing orally disintegrating tablet and a preparation method thereof. Background technique [0002] Orally disintegrating tablets are a new pharmaceutical preparation, which can be absorbed through the sublingual mucosa and directly enter the blood, effectively avoiding the first-pass effect, so the dosage is small, safe and has a rapid effect. Although it is an oral preparation, it can achieve the effect of an injection preparation. Therefore, it is gradually becoming a hot spot in the field of pharmaceutical companies and research and development. The dosage form is mainly to select a suitable fast disintegrating agent, and the tablet made of it has a certain hardness and a certain degree of porosity. When taking it, it does not need water to assist swallowing, and it can quickly disintegrate into fine particles in the mouth, a...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61P9/10A61P29/00
Inventor 张晴龙
Owner 张晴龙
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