Method for preparing sitostamol

A technology for sitostanol and stigmasterol, which is applied in the field of preparation of sitostanol, achieves the effects of reducing raw material cost, simple and easy industrialized production, and reducing preparation cost

Inactive Publication Date: 2005-03-16
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The amount of stanols in nature is very small, and the unsaturated double bonds of sterols are mainly reduced to saturated bonds by catalytic hydrogenation, and phytosterols are converted into corresponding stanols by hydrogenation. It is prepared by catalytic hydrogenation of raw materials under a certain pressure, such as US patent US: 20020045773, US: 20030004361, US: 6 147 235, there is no production of sitostanol in China

Method used

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  • Method for preparing sitostamol

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Add reaction solvent isopropanol 250ml (3.2mol), 10%Pd / C catalyst consumption: 0.2% (336.8mg) of stigmasterol in the three-necked glass flask that reflux condenser is housed, heat up to 65 ℃, pass into Hydrogen, ventilation rate is 350ml / min, heat preservation and activation for 0.5h. The temperature was raised to 82° C., 16.84 g (0.04 mol) of stigmasterol was added, the reaction pressure was 101 kPa, the reaction was carried out for 10 h, and the reaction conversion rate was 95.71%. 10% Pd / C catalyst: industrial product, produced by Changzhou Kefeng Chemical Reagent Factory.

Embodiment 2

[0039] The reaction medium is ethanol, the reaction temperature is 78° C., the other conditions are the same as in Example 1, and the reaction conversion rate is 86.30%.

Embodiment 3

[0041] The reaction medium is n-butanol, the reaction temperature is 90° C., the other conditions are the same as in Example 1, and the reaction conversion rate is 92.23%.

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Abstract

The invention provides a method for preparing sitostamol from stigmasterol through catalyzed hydrogenation, wherein organic solvent is used as reaction medium, palladium / carbon is used as catalyst for catalyzing hydrogenation of stigmasterol under atmosphere pressure or low pressure. The method can lower the preparation cost of sitosterane alcohols.

Description

technical field [0001] A preparation method of sitostanol relates to the preparation of sitostanol by catalytic hydrogenation of stigmasterol. Background technique [0002] Sterols widely exist in eukaryotic cells, which are the basic components of animal and plant cells and widely exist in animals and plants. In nature, phytosterols mainly exist in the form of stigmasterol, sitosterol, campesterol and saturated phytosterols (ie stanols). Sitosterol and sitosterol are mainly used in food. They are used to lower blood lipids in the West. Their cholesterol-lowering properties are very significant. Some animal and clinical studies believe that sitosterol is more effective than sitosterol in inhibiting cholesterol absorption and lowering cholesterol concentration. . The amount of stanols in nature is very small, and the unsaturated double bonds of sterols are mainly reduced to saturated bonds by catalytic hydrogenation, and phytosterols are converted into corresponding stanols...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07J9/00
Inventor 裘爱泳谢敏浩
Owner JIANGNAN UNIV
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