Method for producing 2-hydroxyisobutyric acid and methacrylic acid from acetone cyanohydrin

A technology of acetone cyanohydrin and hydroxyisobutyric acid, applied in the direction of chemical instruments and methods, microorganism-based methods, biochemical equipment and methods, etc., can solve the problems of lack, low waste production, enzyme inactivation, etc.
CN1635990AInactive Publication Date: 2005-07-06EI DU PONT DE NEMOURS & CO
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
EI DU PONT DE NEMOURS & CO
Publication Date
2005-07-06
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention relates to a process for the production of 2-hydroxyisobutyric acid in which acetone cyanohydrin is converted to 2-hydroxyisobutyric acid using a catalyst having nitrilase activity or using a catalyst having combined nitrile hydratase and amidase activity acid. The invention also relates to the production of methacrylic acid in which 2-hydroxyisobutyric acid prepared with said catalyst is dehydrated to produce methacrylic acid.
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Description

field of invention

[0001] The invention is a method for producing 2-hydroxyisobutyric acid using an enzyme catalyst. More specifically, the present invention relates to the use of catalysts with the activity of Pseudomonas facilis 72W nitrilase or a combination of Pseudomonas testosterone 5-MGAM-4D or Pseudomonas testosterone 22-1 nitrile hydratase and Amidase-active catalyst for the production of 2-hydroxyisobutyric acid from acetone cyanohydrin. 2-Hydroxyisobutyric acid can be used as an intermediate in the production of methacrylic acid. Background of the invention

[0002] Methacrylic acid and its esters are widely used in the production of polyacrylate sheets, cast products, coatings and impact modifiers. It is also used in products such as detergent builders, flow modifiers, motor oil additives, insoluble inks, paints and polishes. Although several production methods for the preparation of methacrylic acid exist, the hydrolysis of methacrylamide sulfate (prepared wi...

Claims

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