Novel pharmaceutical dosage forms and method for producing same
A pharmaceutical dosage form and dosage form technology, applied in the field of new dosage forms
Inactive Publication Date: 2005-07-13
SMITHKLINE BECKMAN CORP
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- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Apparently, the setbacks experienced by drug manufacturers in their attempts to produce tablets by injection molding have prevented them from continuing to research and develop technology using microcellular foams.
Method used
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Examples
Experimental program
Comparison scheme
Effect test
Embodiment 1
[0128] Xylitol 25%
[0129] Hydroxypropylcellulose, grade EF 74%
[0130] Glyceryl Monostearate 1%
[0131] Result: extrusion failed
Embodiment 2
[0133] Xylitol 25%
[0134] Hydroxypropylcellulose, grade EF 69%
[0135] Croscarmellose Sodium 5%
[0136] Glyceryl Monostearate 1%
[0137] Result: Extruded successfully, but not instant
Embodiment 3
[0139] Xylitol 74%
[0140] Hydroxypropylcellulose, grade EF 20%
[0141] Croscarmellose Sodium 5%
[0142] Glyceryl Monostearate 1%
[0143] Result: extrusion failed
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Abstract
Pharmaceutical dosage forms are produced by injection molding mixtures of active agent and polymers under pressure in the presence of gases or supercritical fluids. The rapid release of pressure causes the mixture to form a microporous or ultramicroporous solid. Pressure release takes place inside the mold. The method is especially useful for producing long-lasting fast-dissolving and gastric-retentive tablets.
Description
field of invention [0001] The present invention relates generally to pharmaceutical dosage forms and their manufacture, and more particularly to novel dosage forms in which an active agent is combined with a solid excipient having a foam structure. Background of the invention [0002] Pharmaceutical formulations, especially solid formulations for oral administration, are often provided in the form of so-called "fast dissolving" tablets, which dissolve almost instantaneously, ie within seconds, when they come into contact with saliva in the patient's mouth. Fast-dissolving tablets are especially ideal for use as solid pediatric oral formulations and for dosing adult patients who have difficulty swallowing tablets. [0003] Fast dissolving tablets generally utilize special high solubility formulations and disintegration promoters, and also have a high surface area / volume ratio to facilitate rapid dissolution. In the past, fast-dissolving tablets could not be post-molded due t...
Claims
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IPC IPC(8): A61K9/26A61K9/00A61K9/14A61K9/20A61K47/04A61K47/10A61K47/12A61K47/14A61K47/32A61K47/34A61K47/36A61K47/38
CPCA61J3/10A61J2200/20A61K9/0056A61K9/0065A61K9/2095
Inventor 阿伦·J·克拉克
Owner SMITHKLINE BECKMAN CORP