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Spraying agent of benefiting nose and producing method

The technology of a nasal spray and its manufacturing method is applied in the field of beneficial nasal spray and its manufacturing, which can solve the problems of large local irritation, inconvenient administration, and slow onset of action, and achieve the advantages of less side effects, significant curative effect, and fast absorption Effect

Inactive Publication Date: 2005-08-31
龚振成
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Rhinitis is a common and frequently-occurring disease. At present, it is mostly administered orally, with a slow onset of action, and there are few drugs administered locally in the nasal cavity. There are 15 varieties of western medicine nose drops and 5 traditional Chinese medicine nose drops in the country. , nasal drops have disadvantages such as inconvenient administration, local administration of liquid droplets, large local irritation, and slow absorption.
However, the method of administration of Chinese herbal medicine nasal spray has not been reported yet.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] Take magnolia 20g and ephedra 20g and crush them into coarse powder, use 400ml of ethanol as solvent for percolation, collect the percolation liquid, add 0.5g of borneol, 17ml of Tween, and 170ml of glycerin, mix well, adjust the pH to 6, and set aside; , Angelica dahurica 20g, and Clematis clematis 20g were extracted with water twice, each time for 1 hour, filtered, combined extracts, concentrated to a relative density of 1.10 (60°C), and adjusted to PH6; combined the above two solutions, adjusted to PH6, and added preservatives Ethyl hydroxybenzoate 1g, add water to a total of 1000ml, mix well, let stand, filter, fill into a spray bottle, and obtain.

Embodiment 2

[0012] Take magnolia 80g and ephedra 80g and grind them into coarse powder, use 600ml of ethanol as solvent for percolation, collect the percolation liquid, add 1g of borneol, 17ml of Tween, and 170ml of glycerin, mix well, adjust the pH to 7, and set aside; Add water to extract 50g of Angelica dahurica and 50g of Clematis clematis 4 times, each time for 3 hours, filter, combine the extracts, concentrate to a relative density of 1.30 (90°C), adjust the pH to 7; combine the above two solutions, adjust the pH to 7, and add p-hydroxybenzoic acid Ethyl ester 1g, add water to a total of 1000ml, mix well, let stand, filter, fill into a spray bottle, and you get it.

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PUM

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Abstract

A Chinese medicine in the form in inhalant for treating rhinitis is prepared from 6 Chinese-medicinal materials including magnolia flower, xanthium fruit, ephedra, borneol, etc through percolation, extracting, concentrating, regulating pH value, mixing, filtering and loading in repellant bottle.

Description

Technical field: [0001] The invention relates to a medicament made of Chinese herbal medicine, in particular to a nasal spray for treating rhinitis and a manufacturing method thereof. Background technique: [0002] Rhinitis is a common and frequently-occurring disease. At present, it is mostly administered orally, with a slow onset of action, and there are few drugs administered locally in the nasal cavity. There are 15 varieties of western medicine nose drops and 5 traditional Chinese medicine nose drops in the country. , nasal drops exist inconvenient administration, and the local administration of liquid droplets causes large local irritation and slow absorption. However, the method of administration of Chinese herbal medicine nasal spray has not been reported yet. Invention content: [0003] The purpose of the present invention is to solve the uniformity of local drug administration in the nasal cavity, and improve the absorption rate and effectiveness of the medicine...

Claims

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Application Information

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IPC IPC(8): A61K9/12A61P11/02
Inventor 陈琳钬
Owner 龚振成