Carbamate-substituted pyrazolopyridines

A compound and hydrate technology, which is applied in the direction of pharmaceutical combination, organic chemistry, medical preparations containing active ingredients, etc.
CN1665811AInactive Publication Date: 2005-09-07ADVERIO PHARMA
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
ADVERIO PHARMA
Publication Date
2005-09-07
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention relates to compounds which stimulate soluble guanylate cyclase, to the preparation thereof and to the use thereof as medicaments, in particular as medicaments for the treatment of cardiovascular disorders and / or sexual dysfunction.
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Description

[0001] technical content

[0002] The present invention relates to compounds stimulating soluble guanylate cyclase, their preparation and their use as medicaments, in particular as medicaments for the treatment of cardiovascular disorders and / or sexual dysfunction. Background technique

[0003] One of the most important cellular delivery systems in mammalian cells is cyclic guanosine-phosphate (cGMP). Together with nitric oxide (NO), which is released from the endothelium and transmits hormonal and mechanical signals, it forms the NO / cGMP system. Guanylate cyclase catalyzes the biosynthesis of cGMP from guanosine triphosphate (GTP). Representatives of this family of substances disclosed so far are divided into two groups according to structural features and ligand types: particulate guanylate cyclases that can be stimulated by natriuretic peptides and soluble guanosines that can be stimulated by NO acid cyclase. Soluble guanylate cyclase is composed of two subunits and most...

Claims

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