Semi-solid oral formulation of Chinese medicine

A semi-solid and preparation technology, which is applied in drug delivery, drug combination, pharmaceutical formulation, etc., and can solve problems such as gels that have not been reported yet

Inactive Publication Date: 2005-09-14
QIHUANG PHARMA TECH & INVESTMENT
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  • Abstract
  • Description
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  • Application Information

AI Technical Summary

Problems solved by technology

But as the gel of traditional Chinese medicine preparation has not yet seen report

Method used

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Examples

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Comparison scheme
Effect test

preparation example Construction

[0071] The preparation method of Chinese medicine semi-solid preparation of the present invention generally comprises the following steps:

[0072] (1) The step of preparing the Chinese medicine extract extract, if necessary, before preparing the extract, there is a step of extracting volatile oil;

[0073] (2) The step of dissolving the gel matrix;

[0074] (3) a step of mixing the above-mentioned medicinal extract of (1) with the dissolving gel matrix of the above-mentioned (2);

[0075] (4) the step of adding the volatile oil obtained in the previous (1) to the mixed mixture if necessary;

[0076] (5) A step of adding necessary formulation additives, if necessary, before or after the above-mentioned mixing.

[0077] Because the process of extracting the extract belongs to the common knowledge well known in the art, it is not intended to be too limited in the present invention.

[0078] It should be noted that the active ingredients of the medicinal materials contained in...

Embodiment 1

[0088] Codonopsis 960g, Atractylodes macrocephala (stir-fried) 1440g, citrus aurantium (stir-fried) 960g, tangerine peel 960g, malt (stir-fried) 960g, hawthorn (fried) 720g

[0089] The above 6 flavors, Atractylodes macrocephala, Citrus aurantii, and tangerine peel were distilled with 5 times the amount of water for 4 hours to obtain 13.1 g of volatile oil, which was set aside. After distillation, the medicinal liquid is collected in another device. Codonopsis, malt, and hawthorn add 10 times the amount of water and decoct for 1.5 hours. Filter out the medicinal residues, combine them with Atractylodes Rhizoma Atractylodes Rhizoma Atractylodes Rhizome, Fructus Citrifolia, and Tangerine Peel after extracting the volatile oil, add 8 times the amount of water, decoct for 1 hour, and filter out the medicinal residues. The decoctions were combined several times, concentrated to a specific gravity of 1.32 (by heat measurement at 80°C), and 1.52 kg of thick extract was obtained.

...

Embodiment 2、3

[0094] Except that the amount of volatile oil obtained is 12.8g and 13.3g respectively, and the specific gravity of the concentrated extract obtained by concentration is 1.35 and 1.30 respectively, according to the same process and composition of medicinal materials in Example 1, two batches of gels are obtained, and the yield of finished products is 1964 capsules and 1950 grains.

[0095] The gels obtained in the above Examples 1-3 contain about 3 g of medicinal material in each capsule on average. After inspection (detection method is by " commonly used Chinese herbal medicine active ingredient content determination ", 305,770 pages, edited by Chen Fakui, People's Medical Publishing House, 1997), characteristic component naringin content in the gel of embodiment 1~3 gained has no significant difference.

[0096] The determination method of naringin content is as follows:

[0097] Determination by high performance liquid chromatography. The chromatographic column is an ODS...

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Abstract

Disclosed is a semi-solid oral formulation of Chinese medicine which comprises traditional Chinese medicinal extract and gel base material, its preparing process comprises the steps of preparing Chinese medicinal extract, dissolving the gel base material, finally mixing the extract with the dissolved gel base material.

Description

technical field [0001] The present invention relates to a new oral preparation of traditional Chinese medicine, more specifically, the invention relates to a semi-solid gel preparation of traditional Chinese medicine, which can improve the drug compliance of patients while maintaining the efficacy of the medicine, and at the same time make the administration more convenient. Background technique [0002] The prescription of Jianpi Pill is a traditional famous prescription for treating spleen deficiency and lack of food. According to research, Jianpi Pills were first recorded in Volume 1 of Zhang Sanxi's "Six Essentials of Medicine Therapeutic Methods" in the Ming Dynasty. The composition of the prescription: 4 liang each of ginseng and Atractylodes macrocephala, 1 liang of hawthorn, 1 liang of malt, and 1 liang of tangerine peel. Shenqu paste is a pill, which is mainly used for inconvenient transformation after eating, so eating less. This pill is recorded in Wang Ang's "Y...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61P1/14
Inventor 王文胜
Owner QIHUANG PHARMA TECH & INVESTMENT
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