Process for preparing high purity scutellarin

Abstract

The present invention discloses preparation process of high purity scutellarin from baicalin. Baicalin is added into water solution of sulfuric acid and reacted at 50-70 deg.c for 10-15 min to obtain separated coarse crystal product; and the coarse product is purified with acetone to obtain high purity scutellarin. Thus prepared scutellarin product, high efficiency liquid phase test process shows, has scutellarin content of 96 % or over. The process has short reaction time, mild reaction condition, simplicity and low cost, and is suitable for industrial production.

Description

technical field The invention belongs to the extraction method of traditional Chinese medicine, in particular to the method for preparing baicalein from baicalin. Background technique Scutellaria baicalensis is the dry root of Scutellaria baicalensis Georgi, which has the functions of clearing away heat and dampness, purging fire and detoxification, stopping bleeding and preventing miscarriage. Baicalein and Baicalin are the main components of Scutellaria baicalensis. They have exact chemical structures, and their structural formulas are: R=H baicalein R=glucuronic acid baicalin Studies in recent years have found that these two extracts of Scutellaria baicalensis have antibacterial and antiviral effects, especially baicalein has more liver protection, gallbladder diuresis, free radical scavenging and antioxidant effects, anticoagulant and antithrombosis, and inhibition of pancreatic enzymes. Activity, effect on biofilm, anti-cancer, dual regulation on smooth muscle, ...

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Problems solved by technology

Although this process can produce baicalein with higher purity, there are still problems such as deep color (many impurities), long reaction time, high requirements for reaction conditions, troublesome refining process, etc. of the product, which will cause poor quality and industrial cost too high

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