Method for preparing cefixime
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- 天津市医药集团技术发展有限公司
- Publication Date
- 2005-11-16
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Abstract
Description
technical field
[0001] The invention belongs to the technical field of medicine synthesis, and relates to the synthesis of cephalosporins, more specifically, a preparation method of the third-generation oral cephalosporin cefixime. Background technique
[0002] Cefixime (II), chemical name: (6R,7R)-7-[(Z)-2-(2-amino-4-thiazolyl)-2-(carboxymethoxyimino)acetamido]- 8-Oxo-3-vinyl-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid trihydrate is a semi-synthetic third-generation oral cephalosporin with Both Gram-positive bacteria and Gram-negative bacteria have strong antibacterial effect and are highly stable to β-lactamase.
[0003] According to literature reports, cefixime is generally prepared by the following synthetic method.
[0004]
[0005] where R 1 For hydrogen or carboxyl protecting group p-methoxybenzyl, benzhydryl, etc., R 2 It is a lower aliphatic hydrocarbon group such as carboxyl protecting group methyl, tert-butyl, etc. Z is chlorine or mercaptobenzoth...