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Drug-dropping soft capsule and its preparing process

A technology of soft capsules and capsule materials, which is applied in the directions of capsule delivery, medical preparations containing active ingredients, plant raw materials, etc., can solve the problems of easy loss of volatile ingredients, poor sealing performance of hard capsules, unstable effective dose, etc. The effect of short solution time, reduced raw material cost and fast absorption in the body

Inactive Publication Date: 2006-01-18
江西欧氏药业有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, with the development of modern research on traditional Chinese medicine, it is not difficult to find that hard capsules have poor sealing properties and volatile components are easy to lose, resulting in unstable effective doses and affecting clinical applications.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Embodiment 1, the preparation of Keke soft capsule

[0034] 1. Preparation of active ingredients:

[0035] Take 240g ephedra, 240g licorice, 240g bitter almond, 240g radish, 75g platycodon, 75g gypsum, 75g gypsum, the above seven flavors, ephedra and papium shell, and grind them into fine powder, sieve, leave 110g of fine powder for later use, and use acidic aqueous solution ( Use 10% hydrochloric acid solution to adjust the pH value to about 5), decoct twice, each time for two hours, filter, adjust the filtrate to 7 with 10% sodium hydroxide solution, and prepare the liquid medicine for later use; Once, each time for 1 hour, filter, the filtrate is combined with the above solution, concentrated to a thick paste, added ephedra and poppy shells to subdivide, mixed evenly, dried at 60-70°C, and pulverized into fine powder to obtain 300g compound active ingredient.

[0036] 2. Preparation of contents: 300 grams of PEG-400, 6 grams of PEG-40000 and 30 grams of propylene gl...

Embodiment 2

[0039] Embodiment two, the preparation of Keke soft capsule

[0040] 1. Preparation of active ingredients:

[0041] 2. Preparation of contents: 150 grams of PEG-400, 0.15 grams of PEG-6000 and 1.5 grams of propylene glycol, the method is the same as in Example 1.

[0042] 3. Preparation of capsule material: Take 5000 grams of gelatin and 2500 grams of water, heat to 70°C, take 500 grams of glycerin, stir, vacuumize for 1 hour, mix with the above gelatin, keep warm at 70°C overnight.

[0043] 4, compressed soft capsule: with embodiment one.

Embodiment 3

[0044] Example 3: Preparation of Keke Soft Capsules

[0045] 1, prepare active ingredient: with embodiment one.

[0046] 2. Preparation of contents: 600 grams of PEG-400, 30 grams of PEG-4000 and 300 grams of propylene glycol, the method is the same as in Example 1.

[0047] 3. Preparation of capsule material: Take 5,000 grams of gelatin and 10,000 grams of water, heat to 70°C, take 5,000 grams of glycerin, stir, vacuumize for 1 hour, mix with the above gelatin, keep warm at 70°C overnight.

[0048] 4, compressed soft capsule: with embodiment one.

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PUM

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Abstract

The invention relates to a novel dosage form of capsule preparation for treating cough, which comprises content and capsule material, the content includes compound active constituents, dispersing agent and suspension auxiliary agent by the weight ratio of 1:0.5-2:0.0005-0.1. The content may also comprise compound reactive component, diluent, suspension auxiliary agent and wetting agent by the weight ratio of 1:0.5-2:0:0.01-1:0.001-0.1. The capsule material basically comprises gelatin, plasticizing agent and water by the weight ratio of 1:0.1-1:1-0.5-2.

Description

technical field [0001] The invention relates to a new dosage form of Keke hard capsule and Keke soft capsule and a preparation process thereof. Background technique [0002] Keke capsule is derived from the "Ma Xing Gan Shi" soup in the classic prescription of traditional Chinese medicine "Treatise on Febrile Diseases". The poppy shell in the prescription has been an important medicine for relieving cough since ancient times, and it is specially used for refractory cough and asthma. "Danxi Xinfa" records that "poppy shell is often used to treat cough, so there is no need to doubt it"; . Traditional Chinese medicine believes that the lungs are delicate organs, and exogenous infections or internal injuries can easily cause dysfunction in the circulation and descending of lung qi, resulting in coughing, asthma and other symptoms. The combination of various medicines in Keke Capsules has the effects of relieving cough, relieving asthma and eliminating p...

Claims

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Application Information

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IPC IPC(8): A61K36/899A61K9/48A61P11/14
Inventor 赵凯苑洪忠宋学哲肖宝华
Owner 江西欧氏药业有限责任公司