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Dripping pills of diosgenin and its preparation process

A technology of diosgenin and diosgenin, which is applied in the directions of pill delivery, pharmaceutical formulations, and medical preparations containing active ingredients, can solve the problems of infeasibility, loss of practicability, and large changes in the preparation process, and achieves improved biological efficiency. The effect of improved utilization, accuracy, and small difference in pill weight

Inactive Publication Date: 2006-02-08
COSCI MED TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0008] The preparation method disclosed in the above-mentioned documents is obviously only a laboratory experimental method. Due to the particularity of the drop pill preparation process, in addition to the need to use equipment dedicated to the preparation of drop pills, its specific formula (i.e. the types of raw materials and auxiliary materials) and the selection of its ratio) vary greatly with the difference of medicine and preparation process, according to the preparation process of the diosgenin dripping pills disclosed in the prior art, although it is possible to prepare the dripping pills in the patent law sense, its preparation The process obviously does not have the feasibility of being implemented in industry. Therefore, it is obviously impossible to obtain diosgenin dripping pills that can be applied to industrialized production and meet the quality indicators of dripping pill preparations stipulated in the national drug standards. , thus losing the practicability of really applying to the treatment of patients

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  • Dripping pills of diosgenin and its preparation process

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Experimental program
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Effect test

Embodiment Construction

[0030] Now with several groups of specific examples, the preparation method of the diosgenin dripping pills of the present invention will be further described.

[0031] [Test prescription]

[0032] 1. Raw material - dioscin

[0033] 2. Base—a mixture of polyoxyl 40 stearate and polyethylene glycol, as follows:

[0034] 2.1 Polyoxyl 40 stearate: polyethylene glycol 2000 =1:1~1:10

[0035] 2.2 Polyoxyl 40 stearate: polyethylene glycol 4000 =1:1~1:10

[0036] 2.3 Polyoxyl 40 stearate: polyethylene glycol 6000 =1:1~1:10

[0037] 2.4 Polyoxyl 40 stearate: polyethylene glycol 10000 =1:1~1:10

[0038] 2.5 Polyoxyl 40 stearate: polyethylene glycol 20000 =1:1~1:10

[0039] 3. The ratio of diosgenin to matrix:

[0040] In g or kg as the unit, diosgenin: matrix = 1:1~1:9

[0041]4. Prepare according to the process of [Preparation Method] 4-7 ​​to obtain Diosgenin Dropping Pills with different specifications.

[0042] [Test content and results]

[0043] Test 1: be 1: 1 in or...

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Abstract

The invention discloses a medicinal composition for treating various diseases, especially a dripping pill of diosgenin and its preparation process, wherein the pill is prepared from polyethylene glycol, polyoxyl (40) stearate as the base material, and diosgenin as the raw material.

Description

technical field [0001] The invention relates to a pharmaceutical composition that can be used for treating various diseases, in particular to an oral preparation of a pharmaceutical composition prepared from diosgenin as a raw material. Background technique [0002] Dioscin belongs to steroidal saponins, which can be hydrolyzed to obtain diosgenin (Dio), which mainly exists in the rhizomes of plants such as Dioscoreaceae, Rosaceae, Caryophyllaceae, among which Dioscinaceae has the most content, mostly Dio derived saponins. Dio is the raw material for the synthesis of steroid hormones and oral contraceptives. In recent years, with the continuous development of separation and extraction technology, a variety of dioscins have been isolated, and it has been found that dioscin not only has a wide range of biological effects, but also has few side effects, a wide range of materials, and low prices. Therefore, the research on dioscin Gaining importance. It can be predicted that ...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61K9/20A61P35/00A61P3/06A61P31/18A61P29/00A61P1/04
Inventor 王锦刚
Owner COSCI MED TECH CO LTD