Multi purpose contact lens care compositions including propylene glycol or glycerin

A contact lens, multifunctional technology for use in the fields of cleaning, treating, multifunctional solutions for treating contact lenses, soaking, and compositions for wetting contact lenses, conditioning, and disinfecting

Inactive Publication Date: 2006-02-08
ADVANCED MEDICAL OPTICS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

A US patent states that traditional buffers other than borate buffers can be used, but only with larger amounts of biguanides

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Prepare a solution by mixing together the following ingredients:

[0048] PHMB (polyhexamethylene biguanide) 1.1ppm (w / v)

[0049] Disodium EDTA 0.02% (w / v)

[0050] Poloxamer 237 (polyoxyethylene-polyethylene 0.05% (w / v)

[0051] Oxypropylene block copolymer)

[0052] Sodium dibasic phosphate (heptahydrate) 0.12% (w / v)

[0053] Monobasic sodium phosphate (monohydrate) 0.01% (w / v)

[0054] HPMC (Hydroxypropylmethylcellulose) 0.15% (w / v)

[0055] Sodium chloride 0.79% (w / v)

[0056] Potassium chloride 0.14% (w / v)

[0057] Adjust pH with NaOH Sufficient to bring pH to 7.4

[0058] Water (USP) qs (Q.S.) 100%

[0059] Approximately 3 mL of this solution is introduced into lens vials containing hydrophilic or soft contact lenses filled with lipid, oily deposits. The contact lenses are kept in this solution at room temperature for at least about 4 hours. This treatment effectively disinfects contact lenses. Furthermore, it was found that a substantial portion of th...

Embodiment 2

[0062] Example 1 was repeated except that different amounts of solution were used to rub and rinse the lenses prior to placement in the eyeglass vials. After at least about 4 hours, the lenses are removed from the solution. The glasses are then placed into the eyeglass wearer's eyes for a safe and comfortable fit.

Embodiment 3

[0064] The solution of Example 1 was used as a long-term soaking medium for hydrophilic contact lenses. Accordingly, approximately 3 mL of this solution was placed in a lens bottle, and the contact lenses were kept in this solution at room temperature for approximately 60 hours. After this soak time, the lens is removed from the solution and placed in the eye of the lens wearer for a safe and comfortable fit. Alternatively, after the lenses are removed from the solution, they are rinsed with an additional volume of the solution and the rinsed lenses are placed in the eye of the lens wearer for safe and comfortable wearing.

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PUM

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Abstract

Multi-purpose solutions for contact lens care provide substantial lens wearer / user comfort and / or acceptability. Such solutions include an aqueous liquid medium; an antimicrobial component, preferably a biguanide polymer present in an amount of 0,00001 % (w / v) to 2 % (w / v); propylene glycol or glycerin in an amount sufficient to increase antimicrobial activity; a surfactant component, preferably a poly (oxyethylene) -poly (oxypropylene) block copolymer surfactant, in an effective amount; a phosphate buffer component in an effective amount; preferably (2x) a viscosity inducing component, preferably selected from cellulosic derivatives, in an effective amount; and preferably (2x) a tonicity component in an effective amount. Such solutions have substantial performance, comfort and acceptability benefits, which, ultimately, lead to ocular health advantages and avoidance of problems caused by contact lens wear.

Description

[0001] Cross References to Related Applications [0002] This application is a continuation-in-part of U.S. Application Serial No. 10 / 226,851, filed August 23, 2002, which is a continuation-in-part of U.S. Application Serial No. 09 / 968,253, filed October 1, 2001, which was filed October 1, 1999 Continuation of U.S. Application No. 09 / 417,526, now U.S. Patent No. 6,319,883, filed November 13, which is a continuation of U.S. Application No. 08 / 980,033, now U.S. Patent No. 6,063,745, filed November 26, 1997 Apply. The disclosures of these applications and patents are hereby incorporated by reference in their entirety. technical field [0003] The present invention relates to compositions for treating, disinfecting, cleaning, soaking, conditioning, and wetting contact lenses. More particularly, the present invention relates to multifunctional solutions useful for treating contact lenses, e.g., for disinfecting contact lenses, for removing deposits from contact lenses, for soakin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L12/14C11D3/00C11D3/20C11D3/48
CPCA61L12/142C11D3/0078A61L12/14C11D1/008C11D3/2044C11D3/2065A01N47/44C11D3/2003A61L12/143A61L12/141C11D3/48A01N25/02A01N2300/00
Inventor 拉姆·N·德兰理查德·S·格雷厄姆
Owner ADVANCED MEDICAL OPTICS
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