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Receptor function controlling agent

A technology of regulators and functions, applied in the fields of organic chemistry, digestive system, metabolic diseases, etc.

Inactive Publication Date: 2006-02-15
TAKEDA CHEM IND LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] So far, no non-peptidic low molecular weight agonists or antagonists of the GPR40 receptor are known

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 312

[0542] 3-(4-((4-(((2-phenoxypropyl)amino)methyl)benzyl)oxy)phenyl)propanoic acid (Example 312);

Embodiment 330

[0543] 3-(4-((4-((Dibenzylamino)methyl)benzyl)oxy)phenyl)propanoic acid (Example 330);

Embodiment 334

[0544] 3-(4-((4-(((2-imidazo[1,5-a]pyridin-3-ylethyl(phenyl)amino)methyl)benzyl)oxy)phenyl)propanoic acid (Example 334);

[0545] 3-(2-(4-((3-phenoxybenzyl)oxy)phenyl)ethyl)-1,2,4-oxadiazol-5(4H)-one (Reference Example 213).

[0546] As compounds that can be used in the present invention, JP-A Nos. 2002-265457, 2002-212171, 2001-226350, 2001-199971, 2000-198772, Compounds described in JP-A-2000-80086, JP-A-2000-34266, JP-A-09-323983, JP-A-08-311065, etc.

[0547] Examples of salts of compounds that can be used in the present invention include metal salts, ammonium salts, salts with organic bases, salts with inorganic acids, salts with organic acids, salts with basic or acidic amino acids, etc. . Preferable examples of metal salts include, for example, alkali metal salts such as sodium salts and potassium salts; alkaline earth metal salts such as calcium salts, magnesium salts, and barium salts; and ammonium salts. Preferable examples of salts with organic bases include tri...

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Abstract

A GPR40 receptor function controlling agent which contains a compound having an aromatic ring and a group capable of releasing a cation and is useful as a insulin secretion promoting agent or a preventive / remedy for diabetes, etc.

Description

technical field [0001] The present invention relates to a GPR40 receptor function modulator comprising aromatic ring-containing carboxylic acid or its derivatives and a novel compound with GPR40 receptor function regulation function. Background technique [0002] The amino acid sequence of human-derived GPR40 and the DNA encoding it have been described (WO2000 / 22129 and Biochem Biophys Res Commun. 1997, Oct 20; 239(2)). [0003] It is known that aromatic ring-containing carboxylic acids or derivatives thereof have various physiological activities. [0004] Alkanic acid derivatives are known (JP-A-2002-265457). [0005] Isoxazole derivatives that have insulin secretion promoting action and blood sugar lowering action and are useful in the prevention and treatment of diabetes etc. are known (JP-A-2002-212171). [0006] There are known nitrogen-containing five-membered heterocyclic compounds that have blood sugar-lowering and blood-lipid-lowering effects and are useful in the...

Claims

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Application Information

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IPC IPC(8): A61K31/192A61K31/195A61K31/216A61K31/343A61K31/381A61K31/401A61K31/404A61K31/426A61K31/428A61K31/437A61P1/04A61P3/04A61P3/06A61P3/10A61P7/02A61P7/10A61P9/10A61P9/12A61P13/12A61P15/08A61P17/00A61P19/02A61P19/08A61P25/00A61P25/28A61P27/02A61P35/00A61P37/08A61P43/00C07D277/42C07D277/64C07D277/74C07D277/84C07D277/24C07D471/04
Inventor 深津考司佐佐木忍日沼州司伊藤康明铃木伸宏原田征隆安间常雄
Owner TAKEDA CHEM IND LTD
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