Medicine for treating nephrolithiasis and its prepn
A technology of kidney stones and drugs, which is applied in the field of traditional Chinese medicine, can solve the problems of stone removal and kidney damage, and achieve the effect of preventing stone formation and stone recurrence
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experiment example 1
[0022] Experimental example 1. The influence of the present invention on dog's blood pressure, kidney volume and urine output
[0023] 1. Experimental method: We use 31 healthy dogs, both male and female, generally weighing about 8-12.5kg. Excluding 11 deaths due to incomplete data or other causes. 20 cases with complete information.
[0024] Twenty dogs were treated with sodium pentobarbital 50mg / kg under general anesthesia.
[0025] After anesthesia, the common carotid artery was intubated, and the blood pressure of the common carotid artery was directly recorded on the drum.
[0026] Make an incision in the middle of the abdomen, and then find the left kidney, peel off its outer membrane, and then fix it with a renal volumetric device, connect the Mary's air drum, and record it on the drum surface. Record changes in renal volume and indirectly understand changes in renal blood flow.
[0027] Find the left ureter, free, intubate, directly connect to the drip register, and record...
experiment example 2
[0043] Experimental Example 2. The mechanism of "Rongshisu Tablets" on the smooth muscle of rabbit jejunum
[0044] 1. Materials and methods: Choose healthy and heavier rabbits. Ten male and female rabbits are selected for intravenous anesthesia with ethyl carbamate at 1.0g / kg. After general anesthesia, a midline abdominal incision was made to find the jejunum, and the jejunum smoothing machine was cut 2.0cm. Put it in a McDonald’s bath and connect the lever to trace.
[0045] Record the amplitude. Add 10%-8.0ml / kg "Lyolite Tablets" into the Mai's bath. Record the amplitude and compare it before and after administration.
[0046] 2. Results and discussion: Five minutes after the administration, the contraction frequency (increased tension) and amplitude increased obviously.
[0047] "Lyolysin Tablets" have obvious excitatory effects on rabbit jejunum smooth muscle and promote smooth muscle contraction.
[0048] Through simulation experiments of rabbit jejunum smooth muscle, it can...
experiment example 3
[0056] Experimental Example 3. Long-term Toxicity Test Report of Rongshisu Tablets
[0057] 1. Materials and methods
[0058] 1. Animals: 50 rats, raised in the animal room of Changchun College of Traditional Chinese Medicine, weighing 80-110 grams, half male and half male, were randomly divided into four groups, routinely raised during the administration period, and the conditions of each group were the same.
[0059] 2. Drugs: Lithosol tablets produced by the preparation room of the Affiliated Hospital of Changchun College of Traditional Chinese Medicine, powdered drugs and distilled water to prepare a suspension of the required concentration.
[0060] 3. Method: The experiment is divided into 4 groups
[0061] The first group: the control group, were given saline 1ml / 100g body weight by gavage, once a day for three weeks.
[0062] The second group: the low-dose group (equivalent to the clinical adult dosage), 5% lysin tablets 0.108ml / 100g body weight, gavage, once a day, a tota...
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