Use of compounds for the prevention of drug-induced cell toxicity

A cytotoxicity, compound technology, applied in the directions of heterocyclic compound active ingredients, drug combinations, antitoxic agents, etc., can solve the problems of reducing cytotoxicity, not disclosed, etc.
CN1794982AInactive Publication Date: 2006-06-28RECEPTICON
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
RECEPTICON
Publication Date
2006-06-28
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention relates to the use of a compound for the preparation of a medicament for the prevention and / or treatment of induced cytotoxicity, such as nephrotoxicity and ototoxicity, in particular said cytotoxicity is induced as a result of drug treatment. In a preferred embodiment, the compound has at least two nitrogen atoms, more preferably at least two amino groups. The compound of the present invention can block the binding of cytotoxic compounds to megalin receptors, thereby inhibiting the uptake of the cytotoxic compounds into cells. The present invention also relates to novel compounds for use in said treatment, as well as methods of reducing the cytotoxicity of cytotoxic compounds, more particularly gentamicin.
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Description

field of invention

[0001] The present invention relates to the technical field of cytotoxic therapy and discloses compounds and combination medicaments for the above-mentioned therapy. Background of the invention

[0002] The present invention relates to compounds for the prevention of organ damage, particularly kidney and inner ear organ damage resulting from the administration of therapeutic agents.

[0003] Many drugs in clinical use are toxic to organs such as the kidneys and inner ear. Among the well-known drugs are cisplatin, ifosfamide, cyclosporine, amphotericin B, valproate, polymyxin B and therapeutic antibodies. Of particular importance, however, are the aminoglycosides, which are among the most important antibiotics for the treatment of severe bacterial infections. They are preferred agents against Gram-negative bacteria. At present, the market share of aminoglycosides in the field of anti-infective agents is growing rapidly. Most notably due to the general i...

Claims

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