Compound glutamine granules and preparation method thereof

A technology of glutamine and granules, applied in the field of long-acting glutamine preparations and its preparation, to achieve the effect of ensuring curative effect

Inactive Publication Date: 2006-07-12
周有财
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  • Abstract
  • Description
  • Claims
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And to improve the preparation method to obtain the technology o

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  • Compound glutamine granules and preparation method thereof
  • Compound glutamine granules and preparation method thereof
  • Compound glutamine granules and preparation method thereof

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Embodiment 1

[0017] 1. Preparation of raw and auxiliary materials

[0018] 1.1 7 grams of carboxymethyl cellulose, passed through an 80-mesh sieve, was made into a 3wt% aqueous solution, soaked to a transparent paste for subsequent use.

[0019] 1.2L-glutamine 990g, passed through 80 mesh sieve for later use.

[0020] 1.3 Sodium azulene sulfonate inclusion complex

[0021] Weigh 3 grams of sodium azulene sulfonate, 27 grams of β-cyclodextrin, and 990 grams of L-glutamine.

[0022] Inclusion method: Grind β-cyclodextrin with water to form a paste, add sodium azulene sulfonate and continue grinding for 1 hour. Move the ground clathrate into a tray and spread it out (thickness not exceeding 1cm). At 50°C, P 2 o 5 Dry under reduced pressure under desiccant. Grind after drying, and pass through an 80-mesh sieve for later use.

[0023] 2. Soft materials

[0024] Mix azulene sulfonate sodium clathrate and L-glutamine uniformly according to equal amount addition method, add 3wt% carboxymet...

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Abstract

The invention discloses a compound glutamine granule and its preparing process, which consists of coating sodium azulene sulfonate with beta-cyclodextrin to obtain sodium azulene sulfonate inclusion compound, then mixing the inclusion compound with L-glutamine homogeneously, charging 3 wt% of carboxymethyl cellulose solution, stirring homogeneously to obtain soft material, finally granulating the soft material.

Description

technical field [0001] The invention relates to a long-acting glutamine preparation and a preparation method thereof. technical background [0002] Compound glutamine granules refer to granules made from L-glutamine and sodium azulene sulfonate. It is clinically used to treat gastritis and gastric ulcer. [0003] Because the sodium azulene sulfonate contained in this product is easy to decompose when exposed to light, it is difficult to guarantee the product quality during storage. For example, the Japanese Mazilin-S granule was tested according to the Chinese Pharmacopoeia, and its solubility was unqualified, which made it difficult to guarantee the efficacy of the drug. [0004] The general technological process of current granule preparation please refer to figure 1 . The raw materials are obtained after crushing, sieving, mixing and granulating. The current preparation method of compound glutamine granules basically applies the general process of granule preparation...

Claims

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Application Information

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IPC IPC(8): A61K31/198A61K31/185A61K47/40A61K9/14A61P1/04
Inventor 周有财
Owner 周有财
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