Related gene and protein for preventing and treating Japanese blood fluke infection, and its uses

Abstract

The invention discloses a protein sequence for killing Japanese Schistosoma and preventing and treating Japanese Schistosoma infection and the corresponding gene sequence and its usage. The protein sequence uses affinity chromatography, polyacrylamide gel electrophoresis; dialysis, freeze drying and protein amino end test sequence to separating obtain the blood serum albumin from oriental hamster unguent. It uses polyase chain reaction technology to obtain oriental hamster blood serum albumin gene sequence. The gene and the decorated mutant insert into the eukaryon expression holder in the animal body, which can be used in preventing and treating the gene of Japanese Schistosoma infection.

Description

technical field

[0001] The invention relates to biopharmaceuticals, gene medicines and genetic engineering products, and further refers to the separation and purification of serum albumin of oriental voles and the development of genetic engineering products. Development of serum albumin and albumin gene product of oriental vole, and its application in the prevention and treatment of schistosomiasis japonicum. Background technique

[0002] According to the statistics of the World Health Organization, schistosomiasis is prevalent in more than 70 countries around the world, 200 million people are infected with schistosomiasis, 120 million people have clinical symptoms of infection, and about 20,000 people die of schistosomiasis every year. The schistosome in our country is Schistosoma japonicum. Since the founding of New China, my country has made great achievements in the control of schistosomiasis, but there are still 108 counties (cities, districts) in the country that have...

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