Composition of ginkgo leaf extract and dipyridamole, medicine containing same and preparing method thereof

Abstract

The present invention discloses a new ginkgodamole composition, medicine composition prepared hy using it, in particular, injection and their preparation method. Said ginkgodamole composition mainly contains the following components: (by wt%) 18-65% of ginkgo total flavone glycoside, 6-32% of dipyridamole, 4-25% of ginkgo total lactone and the heavy metal content is less than 9.4 ppm (weight), inwhich the ginkgo total lactone is formed from bilobalide, ginkgolide A, ginkgolide B and ginkgolide C according to the weight ratio of 4-40:7-40:3-30:3-40. Said medicine preparation, specially injection have obvious therapeutic effect for curing angiocardiopathy and cerebrovascular diseases.

Description

technical field [0001] The invention relates to a pharmaceutical composition and a preparation method thereof, in particular to a pharmaceutical composition containing total ginkgo flavonol glycosides, dipyridamole, and total ginkgo lactones (based on bilobalide, ginkgolide A, ginkgolide B, ginkgo The ginkgo damocomposition based on the total amount of lactone C), the preparation prepared from the pharmaceutical composition and the preparation method thereof belong to the field of traditional Chinese medicine. Background technique [0002] Ginkgo biloba has the effects of improving cardiovascular and cerebrovascular circulation, providing memory, scavenging oxygen free radicals, and delaying aging. It has dual effects of treatment and health care. The injection prepared from Ginkgo biloba has been used clinically for many years and has achieved good results. Its main active ingredients are total flavonol glycosides of ginkgo biloba and total ginkgolides, and total ginkgolid...

AI Technical Summary

Problems solved by technology

And the Ginkgo biloba injection in the prior art only controls the content of the total flavonoids of Ginkgo biloba, does not control the content of ginkgolide wherein, especially does not control the ratio of bilobalide, ginkgolide A, B and C, and their ratio to the total The proportion of flavonol glycosides, so it is difficult to obtain satisfactory curative effect in the treatment of diseases

In addition, in recent years, compound preparations prepared from Ginkgo biloba extract and dipyridamole have been successively listed on the market. For example, CN1454596A discloses a compound intravenous infusion solution of Ginkgo biloba extract and dipyridamole, wherein every 50 to 500 ml of intravenous infusion contains 4 to 30 mg of total ginkgo flavonoids and 1.5 to 15 mg of dipyridamole, because the content of ginkgolides and total flavonol glycosides in this intravenous infusion is not high, and ginkgolides are not controlled Therefore, the compound preparation is difficult to achieve satisfactory curative effect, and its clinical application value is not high.

The same problem also exists in the freeze-dried powder injection of Ginkgo biloba extract disclosed by CN1176656C and dipyridamole, because the active ingredient content is relatively low, it is also difficult to obtain satisfactory curative effect, and impurities (Ginkgo biloba) in this preparation acids, heavy metals, etc.) have not been effectively controlled, and the safety and stability of the resulting pharmaceutical preparations are poor. Due to the high content of impurities, the side effects are relatively large, and adverse reactions such as allergies and injection pains are prone to occur during injection.