Preventive and/or remedy for diseases accompanied by tissue destruction

Abstract

A preventive and / or a remedy for diseases accompanied by tissue destruction which contains a polypeptide having a granulocyte colony stimulating factor activity as the active ingredient; and a drug mobilizing pluripotent stem cells from a tissue toward peripheral blood which contains a polypeptide having a granulocyte colony stimulating factor activity as the active ingredient.

Description

technical field [0001] The present invention relates to an agent for preventing and / or treating diseases accompanied by tissue destruction, which contains a polypeptide having granulocyte colony-stimulating factor (hereinafter referred to as "G-CSF") activity as an active ingredient, and also relates to mobilizing pluripotent stem cells A drug that enters peripheral blood from tissues, and contains a polypeptide having G-CSF activity as an active ingredient. Background technique [0002] G-CSF is a polypeptide that proliferates or differentiates neutrophil precursor cells and activates mature neutrophils. G -CSF is mainly used to accelerate the proliferation of neutrophils (Shorei ni Manabu G-CSF no Rinsho (Clinic of G-CSF Learned from Cases), edited by Yasuo Ikeda, published by Iyaku Journal, Osaka, pp. 64-92 (1999)). It has recently been reported that G-CSF increases stem cells in peripheral blood (Shorei ni Manabu G-CSF no Rinsho (Clinic of G-CSF Learned from Cases), ed...

AI Technical Summary

Problems solved by technology

[0015] In Japan, as the number of people currently requiring dialysis is close to 170,000, there is a huge clinical demand for kidney regeneration drugs that can completely cure renal insufficiency, but there is really no other effective treatment except for kidney transplantation

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