Formulation prepared from effective parts of red sage root and moutan bark, its compound preparation method and medical application

A technology of effective parts and salvia miltiorrhiza, applied in medical preparations containing active ingredients, drug delivery, drug combination, etc., can solve the problems of quality control standards and imperfect processes, low bioavailability, unstable quality, etc., and achieve improvement Microcirculation, reducing myocardial oxygen consumption, and antithrombotic effects

Inactive Publication Date: 2006-09-06
烟台同和医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

All existing products have defects such as unstable quality, large dosage, poor s

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0066] Preparation of total salvianolic acid and total tanshinone from effective parts of Danshen:

[0067] Method 1: Decoct the powder or decoction pieces of Danshen with 5 times the volume (V / W) of water twice, each time for 1 hour, precipitate with 40% concentration of alcohol, filter, and recover ethanol under low temperature and reduced pressure below 40°C to nothing. Alcohol smell, filter, the filtrate is then subjected to macroporous adsorption resin D201, washed with water to remove water-soluble impurities, and then eluted with 80% ethanol to obtain the alcohol eluent, the ethanol is recovered under reduced pressure, and when it reaches a certain density, it is vacuum-dried to obtain Salvia miltiorrhiza The effective part of total salvianolic acid. It is brown-yellow powder with a yield of 7-10%. The content of monophenolic acid B is 50-55%.

[0068] Method 2: Decoct the powder or decoction pieces of Danshen with 5 times the volume (V / W) of water twice, each time fo...

example 2

[0073] Preparation of total paeonol from the effective part of paeonol:

[0074] Add 3 times the amount of water to the powder or decoction pieces of paeonol, soak for 24 hours, steam distill, collect the escaping matter, stop the distillation when the escaping matter is transparent and free from white turbidity, and let it cool down for 24 hours to allow it to precipitate and crystallize naturally , The crude product of paeonol was obtained by filtration and crystallization. The yield is 3-8%. Recrystallize with ethanol to obtain white needle-like crystals of paeonol.

example 3

[0076] Preparation of effective parts of Danshen Dancortex:

[0077] Method 1: Add 5 times the amount of water to the powder or decoction pieces of Danshen and paeonol (2:1), soak for 24 hours, steam distill, collect the escaping matter, and stop the distillation when the escaping matter is transparent without white turbidity. Cool and stand for 24 hours to allow natural precipitation of crystals, and filter out the crystals to obtain the crude product of paeonol. The medicinal liquid is filtered, the filtrate is precipitated with 40% ethanol, filtered, the ethanol is recovered under reduced pressure at low temperature until there is no alcohol smell, filtered, concentrated, and vacuum-dried to obtain brown-yellow salvianolic acid powder of salvia miltiorrhiza. The powder of total salvianolic acid of salvia miltiorrhiza and the crude product powder of paeonol are mixed to obtain a preparation containing total salvianolic acid of salvia miltiorrhiza and effective fractions of t...

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Abstract

This invention is about effective parts preparation of salvia miltiorrhizae and root bark of tree peony and its compound making method and medical usages, and the medical usages come down to coronary disease, anginapectoris, cerebrovascular disease, hypertension and hyperlipemia prevention. This invention contains preparation of overall tanshinade and overall tanshinone in the both effective parts, of overall paeonol in root bark of tree peony, of other medicine clathrate compound and of salt. Different effective parts can be mixed after separately extraction or mixing extracted, and their fat-solubility compounds can be included by various cyclodextrins or can be made to salt such as sodium sulfonate. Different effective parts can be mixing freeze dried and further made to injection or powder injection or any other preparation, or can be used as compound drug by mixing with other drugs (such as borneol) or drug preparation (such as dalbergia oil, storax,xiangfu or chuanxiong rhizome).

Description

technical field [0001] The present invention relates to preparations extracted from salvia miltiorrhiza and paeonol and its medical use, preparation and other medicine compound preparations and uses thereof. Background technique [0002] Cardiovascular disease and cerebrovascular disease are the main diseases that threaten human health. In recent years, the morbidity and mortality of cardiovascular and cerebrovascular diseases in my country have been increasing year by year. Traditional Chinese medicine plays an important role clinically in cardiovascular and cerebrovascular diseases due to its unique advantages such as definite curative effect and less toxic side effects. [0003] Salvia miltiorrhiza is a species recorded in the Pharmacopoeia, which is the root and rhizome of Salvia miltiorrhizaBge. It has the functions of promoting blood circulation, removing blood stasis, tranquilizing the mind, expanding coronary arteries, increasing coronary flow, improving myocardial...

Claims

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Application Information

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IPC IPC(8): A61K36/71A61K9/00A61P3/06A61P9/04A61P9/06A61P9/10A61P9/12
Inventor 王泽君吴新华张传林王金祥孙兰亭
Owner 烟台同和医药科技有限公司
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