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Pharmaceutical uses of hesperidin or its composition

A technology of neohesperidin and its composition, which is applied in the field of pharmaceutical application of neohesperidin or its composition, can solve the problems of no reported neohesperidin, achieve strong pharmacological effects, good medicinal prospects, and low toxicity Effect

Active Publication Date: 2006-09-27
JIANGZI QINGFENG PHARMACEUTICALS INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It has been used as a bittering agent, a sweating agent, and also has the effect of lowering cholesterol and treating acute and chronic bronchitis, but there is no report on the application of neohesperidin to promote gastric motility

Method used

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  • Pharmaceutical uses of hesperidin or its composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Citrus aurantium fine powder 600g, extract 3 times with 70% ethanol (crude drug: solvent weight ratio is 1: 8; 1: 6; 1: 6), combine the extracts, recover ethanol until there is no alcohol smell, add distilled water to 600ml, water The solution was sequentially extracted with petroleum ether, ethyl acetate and n-butanol, 300ml each time. The n-butanol extraction part was concentrated and dried to obtain 82g, which was put on a D101 macroporous resin column, and eluted with water, 25% ethanol, 50% ethanol and 95% ethanol in sequence, and the 50% ethanol eluted part was concentrated and dried to obtain 20% The above mixed total glycosides (47g) of neohesperidin were separated by silica gel column chromatography to obtain pure neohesperidin (95%, 20g). The chemical structure of the above pure product was determined by comparing with the IR, UV, NMR, m.p. and TLC of the standard neohesperidin.

Embodiment 2

[0033] Thoroughly mix neohesperidin (2g) and naringin (18g) at a ratio of 1:9, stir and grind to obtain a composition (20g) of neohesperidin and naringin.

Embodiment 3

[0035] Neohesperidin (10g) and naringin (10g) were thoroughly mixed at a ratio of 1:1, stirred and ground to obtain a composition (20g) of neohesperidin and naringin.

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PUM

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Abstract

The present invention discloses the use of neohesperidin and its composition in preparing gastric power promoting medicine. Neohesperidin and its composition is used in preparing medicines for treating stomach distention, indigestion and infantí»s anorexia.

Description

technical field [0001] The present invention relates to the use of neohesperidin or its composition in the preparation of drugs for promoting gastric motility. Background technique [0002] In recent years, human beings have made great progress in the understanding of gastric motility and its dysfunction. As one of the important physiological functions of the human stomach, motility has received more and more attention and research from the medical community. Insufficient gastric motility often leads to diseases such as bloating, indigestion or anorexia in children. There are already many chemical drugs that promote gastric motility, such as domperidone, cisapride, erythromycin, etc., but their effects are limited, and their clinical application is limited due to problems such as high price and many side effects. [0003] There are many compound prescriptions of traditional Chinese medicine that have the effect of promoting gastric motility, such as Sini Powder, Banxia Xiex...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P1/14
Inventor 孙继寅唐春山王广基叶文才孙旭
Owner JIANGZI QINGFENG PHARMACEUTICALS INC
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