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Plant fiber hard capsule envelope and fabrication method thereof

A hard capsule shell and plant technology, applied in the field of hard capsule shell preparation, can solve problems such as easy cracking and breaking of capsule preparations, increased capsule friability, easy softening and deformation of capsules, etc., to achieve novel products, stable performance, and high content The effect of low water

Active Publication Date: 2006-10-04
烟台东方神州生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This kind of capsule prepared from animal sources is subject to many restrictions in use. First, the water content of the capsule shell is strictly required, which increases the friability of the capsule, which is not conducive to the filling of drugs, especially when the capsule is filled with some hygroscopic ingredients. The moisture in the shell is easily absorbed by the filling, which makes the capsule preparation easy to crack and break during storage, which affects the product quality
Second, the gelatin capsule shell needs to be stored in a constant temperature and humidity environment. If the temperature is too high, the capsule will easily soften and deform, and if the temperature is too low, it will be brittle.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment 1: transparent capsule shell

[0027] The glue formula of this transparent capsule shell is:

[0028] Ingredients Dosage

[0029] Hydroxypropyl Methyl Cellulose 18kg

[0030] Agar Gum 0.5kg

[0031] Glycerin 0.5kg

[0032] water 100kg

[0033] Absolute ethanol 0.79kg (1000ml)

[0034] Weigh 0.5kg of agar and dissolve it in 65kg of pure water with a temperature of 90°C, then stir continuously until it is completely dissolved, then slowly put 18kg of hydroxypropyl methylcellulose into the sol tank, stir continuously, and wait until the temperature of the glue drops Add 0.5kg of glycerin at 60°C, and inject 35kg of hot water at 60°C into the sol tank at the same time, and keep stirring. When the temperature of the glue in the sol tank drops to 50°C, add 1000ml of absolute ethanol, and stir evenly. Put it at 45°C and keep it warm until the air bubbles in the glue are removed. Put the cured glue into the glue tank. The temperature of the glue in the glue tan...

Embodiment 2

[0035] Embodiment 2: transparent capsule shell

[0036] The formula of the transparent capsule shell is:

[0037] Ingredients Dosage

[0038] Hydroxypropyl Methyl Cellulose 17kg

[0039] Agar Gum 1.0kg

[0040] Glycerin 0.5kg

[0041] water 100kg

[0042] Absolute ethanol 0.79kg (1000ml)

[0043] Weigh 1 kg of agar gel and dissolve it in 65 kg of pure water at a temperature of 90 ° C, then stir continuously until it is completely dissolved, then slowly put 17 kg of hydroxypropyl methylcellulose into the sol tank, stir continuously, and wait until the temperature of the gel solution drops When it reaches 60°C, add 0.5kg glycerin and inject 35kg of 60°C water into the sol tank at the same time, and keep stirring. When the temperature of the glue in the sol tank drops to 50°C, add 1000ml of absolute ethanol. Keep warm at ℃ until the air bubbles in the glue are removed, then put the cured glue into the glue dipping tank, the temperature of the glue in the glue dipping tank i...

Embodiment 3

[0044] Embodiment 3: transparent capsule shell

[0045] The formula of the transparent capsule shell is:

[0046] Ingredients Dosage

[0047] Hydroxypropyl methylcellulose 16.5kg

[0048] Agar Gum 1.5kg

[0049] Glycerin 0.5kg

[0050] water 100kg

[0051] Absolute ethanol 0.79kg (1000ml)

[0052]Weigh 1.5kg of agar gel and dissolve it in 65kg of hot purified water at 90°C, then stir continuously until it is completely dissolved, then slowly put 16.5kg of hydroxypropyl methylcellulose into the sol tank, stir continuously, and wait until the temperature of the glue solution drops. When it reaches 60°C, add 0.500kg of glycerin and inject 35kg of 60°C hot water into the sol tank at the same time, and keep stirring. Keep warm at 45°C until the air bubbles in the glue are removed, put the cured glue into the glue dipping tank, the temperature of the glue in the glue dipping tank is within the range of 37°C, and the indoor ambient temperature is kept at 22°C. The template is ...

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Abstract

The invention provides a hard gelatin capsule shell with plant source hydroxypropyl methyl cellulose as the principal ingredient. The invention also provides a process for preparing hard gelatin capsule shell from the plant fiber.

Description

technical field [0001] The present invention relates to the technical field of medicine and health food packaging, in particular, the present invention relates to a hard capsule shell mainly made of plant source hydroxypropyl methylcellulose, and the present invention also relates to the preparation of this new hard capsule shell method. Background technique [0002] The hard capsule shell is an edible packaging material for medicines and health foods. It enters the human digestive system together with medicines or health food preparations, so its quality and safety performance are directly related to the quality and safety performance of health food and pharmaceutical products. The current situation is that, on the one hand, with the continuous improvement of living standards, the people's requirements for the quality and safety performance of raw materials used in medicinal packaging materials are also getting higher and higher; The demand for preparations has increased r...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61J3/07
Inventor 李仁燕
Owner 烟台东方神州生物技术有限公司
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