Process for preparing metformin hydrochloride

A technology of metformin hydrochloride and a production method, applied in the field of medicine and chemical industry, can solve the problems of low product yield, high product cost, large ethanol consumption, etc., and achieve the effects of high product yield and low cost

Inactive Publication Date: 2006-10-11
翟树军
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the existing metformin hydrochloride production technology, the product yield of metformin hydrochloride is low (average about 70%), and viscous substance appears when reaction generates, affects product quality; Used ethanol consumption is big, and product cost is high

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Embodiment 1: in the test room, get concentration and be that 40% dimethylamine aqueous solution 500g is added in anticorrosion reaction vessel, dropwise add concentration and be 31% hydrochloric acid and stir until dimethylamine aqueous solution pH value is 2, stop dripping acid, then Stir for another 2 hours. Concentrate the above solution, when there is crystallization in the anticorrosion reaction container, cool down to 50°C, add 150g of ethanol, 310g of dicyandiamide, and heat to 80°C, carry out vacuum distillation, distill out the ethanol, and then heat the whole solution to The reaction was carried out at 130° C. to obtain the crude metformin hydrochloride.

[0026] The crude metformin hydrochloride was obtained by the above reaction, then lowered to 50°C, added 1000g of ethanol, stirred and cooled to 5°C, discharged from the antiseptic reaction vessel, dried, and recovered ethanol.

[0027] Put the dried crude product into the anti-corrosion reaction container...

Embodiment 2

[0030] Embodiment 2: adopt industrial anticorrosion reactor to carry out production.

[0031] Put 180Kg of dimethylamine aqueous solution with a concentration of 40% into a corrosion-resistant anti-corrosion reaction kettle with a jacket, a temperature stirring reflux device and a vacuum device, and slowly drop 31% hydrochloric acid into the reaction kettle , Stir until the pH value of the aqueous solution is 2, stop dripping acid, then stir the dimethylamine aqueous solution for 5 hours, measure the pH of the dimethylamine aqueous solution = 2, keep the pH at 2 and then turn on the vacuum of the anti-corrosion reactor to concentrate under reduced pressure , when there is crystallization in the reaction kettle, stop the concentration, then lower the temperature to 50°C, add 54Kg of ethanol and 120.6Kg of dicyandiamide, and then distill the above solution to remove the ethanol, and then heat the whole solution to 130°C for reaction The crude product of metformin hydrochloride w...

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PUM

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Abstract

The invention relates to a method of diabecron, using dimethylamine aqueous solution of 40% concentration one value, dropping hydrochloric acid in dimethylamine aqueous solution until the PH value is 2, stopping drop acid, vacuum concentrating solution, cooling to 50deg C after there is crystal in reactor, adding ethanol 0.3 shares, dicyandiamide 0.62-0.67 shares, heating to 80deg C,doing vacuum distillation to distill ethanol, reacting to produce diabecron when heating to 130deg C, adding ethanol 2-3 shares when cooling to 50deg C, discharging when cooling to 5deg C, centrifugal rinsing and drying, drying, recovering ethanol, getting diabecron crude product, drying crude product, adding deionized water 2.5-3 shares, activated char 0.02 shares, ethylene diamine tetraacetic acid disodium 0.003 shares, heating-up to 75-80deg C, cooling to 50deg C again after agitating, adsorbing, filtering, concentrating, adding ethanol 2 shares and agitating, cooling to 5deg C, discharging and centrifugal rinsing and drying, drying to recover the ethanol, getting diabecron completed product, on-spec product's yield of this invention is 75% -80%,the cost is decreased 15%-25% compared with primal method, hasing advantages of high product yield and low cost.

Description

technical field [0001] The invention belongs to the technical field of medicine and chemical industry, and in particular relates to a production method of metformin hydrochloride. Background technique [0002] my country is a big country with a population of 1.3 billion, and the incidence of diabetes is increasing at a rate of 20% every year. So far, the world has not yet developed a specific drug that can cure diabetes, and metformin hydrochloride has obvious effects in treating diabetes in the second stage, and its price is low, which is affordable by ordinary people and accepted by most people. As the number of diabetic patients increases year by year, the demand for this drug will continue to rise. There will be a broad market in domestic and international markets. In the existing metformin hydrochloride production technology, the product yield of metformin hydrochloride is low (average about 70%), and viscous substance occurs when the reaction is generated, which affe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C277/02C07C279/26
Inventor 翟树军郭志强毛运秋
Owner 翟树军
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