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Soft capsule composition containing zine gluconate, Ibuprofen and chlorphenamine maleate

A technology of composition and soft capsule, which is applied in the field of pharmaceutical preparations, can solve the problems of restricting wide application, and achieve the effect of rapid onset of action

Inactive Publication Date: 2006-11-08
ZHEJIANG WANLIAN PHARMA IND +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Limited dosage forms limit the broad application of this combination drug

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Component Content (mg / grain)

[0026] Zinc Gluconate 100.0

[0027] Ibuprofen 150.0

[0028] Chlorpheniramine Maleate 2.0

[0029] soybean oil 400.0

[0030] Tween 80 20.0

[0031] Lecithin 12.0

[0032] Beeswax 20.0

[0033] Total 704.0mg

[0034] Preparation

[0035] Contents of soft capsules: Feed according to the amount of preparing 1000 capsules. Heat the dispersion medium to 50°C, weigh the surfactant according to the required weight unit, stir and mix evenly, then add zinc gluconate, ibuprofen and chlorpheniramine maleate in proportion, and then add the required weight The suspending agent weighed by the unit is stirred evenly to form a uniform and stable liquid medicine. The medicinal liquid is introduced into a soft capsule pill press, and soft capsules are prepared according to a conventional soft capsule preparation method.

Embodiment 2

[0037] Component Content (mg / grain)

[0038] Zinc Gluconate 100.0

[0039] Ibuprofen 150.0

[0040] Chlorpheniramine Maleate 2.0

[0041] soybean oil 300.0

[0042] Tween 80 20.0

[0043] Lecithin 20.0

[0044] Hydrogenated oil 200.0

[0045] Beeswax 10.0

[0046] Total 802.0mg

[0047] The preparation method is the same as in Example 1.

Embodiment 3

[0049] Component Content (mg / grain)

[0050] Zinc Gluconate 100.0

[0051] Ibuprofen 150.0

[0052] Chlorpheniramine Maleate 2.0

[0053] soybean oil 350.0

[0054] Lecithin 10.5

[0055] Hydrogenated oil 100.0

[0056] Stearic acid 28.0

[0057]Total 740.5mg

[0058] Example 3

[0059] Component Content (mg / grain)

[0060] Zinc Gluconate 100.0

[0061] Ibuprofen 150.0

[0062] Chlorpheniramine Maleate 2.0

[0063] soybean oil 530.0

[0064] Glycerin 53.0

[0065] Lecithin 10.6

[0066] Beeswax 53.0

[0067] Total 898.6mg

[0068] The preparation method is the same as in Example 1.

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PUM

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Abstract

The present invention relates to medicine preparation, and especially a kind of soft capsule composition containing zinc gluconate, Ibuprofen and chlorphenamine maleate as active components. The composition consists of active component 1 weight portion, dispersant medium 0.8-3.0 weight portions, surfactant 0.02-0.3 weight portions and suspending agent 0.01-1.0 weight portion. The composition has homogeneous dispersion of medicine component and stable quality.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a soft capsule composition, which contains zinc gluconate, ibuprofen and chlorpheniramine maleate as active ingredients. Background technique [0002] Cold is a common respiratory disease, usually with symptoms such as sneezing, runny nose, nasal congestion, cough, fever, headache, etc., which seriously affects the normal work and life of patients. Zinc gluconate can induce endogenous interferon, enhance human immune function, and inhibit the replication of influenza virus, rhinovirus, herpes simplex virus, etc. In addition, it has been clinically proven that zinc gluconate has significant antitussive and antiasthmatic effects; Ibuprofen is a powerful antipyretic, analgesic and anti-inflammatory drug, which belongs to PG synthase inhibitor. Its analgesic and antipyretic effects are stronger than aspirin, phenylbutazone or acetaminophen; Histamine, which has anti-allerg...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4402A61K9/48A61K31/191A61K31/192A61P11/00A61P29/00A61P31/00
Inventor 陈云芳江磊
Owner ZHEJIANG WANLIAN PHARMA IND
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