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Ebastine tablet and its prepn. method

A technology for ebastine tablets and preparation steps, which is applied in the directions of pill delivery, active ingredients of heterocyclic compounds, and drug combinations, can solve problems such as low dissolution rate of ebastine, and achieve high dissolution rate, good curative effect and high quality. stable effect

Inactive Publication Date: 2006-11-29
杭州仟源保灵药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the invention is to overcome the relatively low technical defect of the dissolution rate of ebastine in the existing ebastine tablet, and propose a higher ebastine tablet and its Preparation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Ebastine tablets are prepared by mixing the following components in the following weight ratio:

[0035] Ebastine 5 Hydroxypropyl Cellulose 2

[0036] Microcrystalline Cellulose 10 Lactose 20

[0037] Starch 5 Magnesium stearate 0.2

[0038] The ebastine is crushed by a high-speed airflow to obtain an ultra-fine powder of more than 300 mesh. Sieve ebastine superfine powder, lactose, starch, hydroxypropyl cellulose, and microcrystalline cellulose through a sieve of more than 60 meshes. Weigh the lactose, starch, hydroxypropyl cellulose, microcrystalline cellulose and ebastine superfine powder that have been sieved through a 60-mesh sieve respectively according to the weight ratio, and check. After the above materials are mixed evenly by hand or mechanical means, they can also pass through a sieve above 60 mesh; use a boiling granulator to spray an appropriate amount of water or starch slurry and other binders, and boil and dry at 40-70 °C. It can also be made into gr...

Embodiment 2

[0041] The component weight proportion in embodiment 1 is changed into following weight proportion, other is the same as embodiment 1.

[0042] Ebastine 20 Hypromellose 20

[0043] Microcrystalline Cellulose 50 Lactose 80

[0044] Starch 50 Magnesium Stearate 1.0

Embodiment 3

[0046] The component weight proportion in embodiment 1 is changed into following weight proportion, other is the same as embodiment 1.

[0047] Ebastine 10 Hypromellose 7

[0048] Microcrystalline Cellulose 25 Lactose 52

[0049] Starch 22 Magnesium stearate 0.7

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PUM

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Abstract

A tablet of Ebastine is prepared from Ebastine, hydroxypropyl cellulose, microcrystalline cellulose, lactose, and adhesive through superfine pulverizing, proportional mixing, granulating, sieving, mixing and tabletting.

Description

technical field [0001] The invention relates to an antiallergic drug tablet and a preparation method thereof, in particular to an ebastine tablet and a preparation method thereof. Background technique [0002] According to data reports, 10% to 20% of the world's population suffers from allergic diseases, and the incidence rate of urticaria is as high as more than 30%, which brings great misery to patients, and even causes disability or death. Ebastine, as a new non-sedating second-generation oxygen piperidine long-acting, potent, quick-acting and selective antihistamine H1 receptor antagonist, has H1 receptor antagonistic effect, from the perspective of pharmacodynamics , pharmacokinetics, toxicological effects, clinical curative effect, dosage, usage, tolerance and clinical comparative studies, etc., the product has good curative effect, long half-life, clinically durable and convenient to take, so It can be the drug of choice for the treatment of ...

Claims

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Application Information

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IPC IPC(8): A61K31/445A61K9/20A61P37/08
Inventor 虞英民陈松军
Owner 杭州仟源保灵药业有限公司
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