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Preparation method of fluoro thiamphenicol metabolite fluoro thiamphenicol amine

A technology for flumethicone amine and fluorine thiamphenicol is applied in the field of preparation of fluorine thiamphenicol metabolite fluorine thiamphenicol, and achieves the effects of high product purity, low preparation cost and simple process steps

Inactive Publication Date: 2006-11-29
INSPECTION & QUARANTINE TECH CENT OF FUJIAN ENTRY EXIT INSPECTION & QUARANTINE BUREAU
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This substance is currently only provided by the Schering-Plough Company (SCH40458) of the United States as a standard reference substance. At present, all the standard substances of fluthiamphenicol amine reported in the literature on the detection of fluthiamphenicol amine are provided by the Schering-Plough Company of the United States. , but there is no literature published in my country on the preparation of fluthiamphenicol amine

Method used

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Examples

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Embodiment Construction

[0006] A preparation method of fluthiamphenicol metabolite fluthiamphenicol amine, characterized in that: using fluthiamphenicol as a raw material, the product can be prepared through acid hydrolysis, liquid-liquid extraction purification, concentration and drying .

[0007] The above-mentioned acid hydrolysis step is that fluthiamphenicol is heated at 100°C for 0.5-5 hours in the medium of 1-6 mol / L hydrochloric acid-methanol.

[0008] The above-mentioned liquid-liquid extraction purification step is to carry out liquid-liquid extraction with ethyl acetate under the condition of dipotassium hydrogen phosphate buffer solution with pH=7.0-10.0.

[0009] The concentration step is to redistribute the organic phase obtained in the liquid-liquid extraction and purification step into an acetic acid solution with a pH of 2.0-5.0, repeat the liquid-liquid extraction step for further purification, keep the organic phase, and then evaporate the organic solvent to dryness.

[0010] The ...

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Abstract

A process for preparing the fluoromethylsulfurylmycin amine includes such steps as providing fluoromethylsulfurylmycin, acid hydrolyzing, liquid-liquid extracting, purifying, concentrating and drying.

Description

technical field [0001] The invention relates to a preparation method of fluthiamphenicol metabolite fluthiamphenicol amine. Background technique [0002] Flurfenicol (florfenicol, CAS#: 76639-94-6), also known as florfenicol, is a common veterinary drug in my country, especially in aquaculture. The metabolite of florfenicol in animals, florfenicol amine, is the labeled residue of florfenicol residues. The European Union, the United States and other countries have regulations on the residues of florfenicol in animal-derived foods. The limit includes fluthiamphenicol's labeled residue, fluthiamphenicol amine. This substance is currently only provided by the Schering-Plough Company (SCH40458) of the United States as a standard reference substance. At present, all the standard substances of fluthiamphenicol amine reported in the literature on the detection of fluthiamphenicol amine are provided by the Schering-Plough Company of the United States. , and there is no literature pu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C317/32C07C315/04C07C317/38
Inventor 杨方
Owner INSPECTION & QUARANTINE TECH CENT OF FUJIAN ENTRY EXIT INSPECTION & QUARANTINE BUREAU