Pharmaceutical composition for treating hypertension and cardiovascular disease

A composition and cardiovascular technology, applied in the field of medicine, can solve problems such as low blood pressure, failure to consider the law of blood pressure changes in patients, and unsatisfactory blood pressure control, so as to increase the level of bradykinin, eliminate adverse reactions, and avoid photolysis. Effect

Inactive Publication Date: 2006-12-27
CSPC OUYI PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The traditional method of taking medicine three times a day does not consider the patient's blood pressure change pattern, but only considers lowering bl

Method used

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  • Pharmaceutical composition for treating hypertension and cardiovascular disease
  • Pharmaceutical composition for treating hypertension and cardiovascular disease
  • Pharmaceutical composition for treating hypertension and cardiovascular disease

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0021] (Examples 1-10)

[0022] The dosage forms of the pharmaceutical compositions of Examples 1 to 10 are tablets, and the raw material formula of each example is the amount for preparing 1000 tablets. The raw material formulations of Examples 1 to 10 are given in Table 1.

[0023] The preparation methods of Examples 1 to 10: the levamlodipine salt, the angiotensin converting enzyme inhibitor, the corresponding cyclodextrin and water are efficiently and rapidly ground for 1 hour, then dried in a vacuum at 400 ° C, pulverized, and passed through a 1000-mesh sieve, Then add the remaining materials, mix with a mixer for 10 minutes, press into tablets, and pack after passing the test.

[0024] How to use: Take orally, once a day, one tablet each time, in the morning.

Example Embodiment

[0025] (Examples 11-13)

[0026] The dosage forms of the pharmaceutical compositions of Examples 11 to 13 are capsules, and the raw material formula of each example is the amount of the drug in preparing 1000 capsules. The raw material formulations of Examples 11 to 13 are given in Table 2.

[0027]Preparation methods of Examples 11 to 13: Levoamlodipine salt, benazepril (or enalapril), cyclodextrin and water were efficiently and rapidly ground for 1 hour, then dried in vacuum at 400° C. sieve, then add the remaining materials, mix in a mixer for 10 minutes, divide into capsules, and pack after passing the test.

[0028] How to use: Take orally, once a day, one tablet each time, in the morning.

Example Embodiment

[0029] (Examples 14-16)

[0030] The dosage forms of the pharmaceutical compositions of Examples 14 to 16 are injections, and the raw material formula of each example is the amount for preparing 100 sterile injections. The raw material formulations of Examples 14 to 16 are given in Table 3.

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Abstract

The invention discloses a pharmaceutical composition for treating hypertension and other cardiovascular diseases, wherein the active constituents include pharmaceutical salts of levamlodipine besylate and angiotensin converting enzyme inhibitor. The invention can not only overcome the drawback of photodecomposition of the levoamlodipine maleate medicaments, but also can increase the dissolving degree by 25%.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating hypertensive cardiovascular disease, belonging to the technical field of medicine. Background technique [0002] Hypertension is the most common cardiovascular disease in the world, and it is also one of the largest epidemics. It often causes complications in the heart, brain, kidney and other organs, and seriously endangers human health. Early prevention and timely treatment are extremely important. Then research and development of drugs for the treatment of cardiovascular diseases has become one of the hot spots in the field of medical research. [0003] In the treatment of hypertension, Pfizer's "Norvasc", ie amlodipine besylate, is widely used in clinical practice. It is a new generation of calcium antagonist, which is recognized as a safe and effective antihypertensive drug by the US FDA. Amlodipine is a new generation of long-acting, basic dihydropyridine calcium channel antago...

Claims

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Application Information

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IPC IPC(8): A61K31/4422A61K45/06A61K9/20A61K9/48A61P9/12A61K31/40
Inventor 郭卫芹李国聪张育高志峰
Owner CSPC OUYI PHARM CO LTD
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