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Compounds for dual photodiagnosis and therapy

A compound and composition technology, applied in the field of new compounds, can solve the problems of type 2 mechanism failure, prolonged skin photosensitivity, low singlet oxygen quantum yield, etc.

Inactive Publication Date: 2007-01-10
MALLINCKRODT INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, it has been shown that photofrin II has several disadvantages: low molar absorptivity (ε=3000M -1 ), low singlet oxygen quantum yield (Φ=0.1), chemical homogeneity, aggregation, and prolonged skin photosensitivity
Additionally, some tumors have hypoxic regions, which disable the type 2 mechanism

Method used

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  • Compounds for dual photodiagnosis and therapy
  • Compounds for dual photodiagnosis and therapy
  • Compounds for dual photodiagnosis and therapy

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Embodiment Construction

[0047] The present invention discloses compounds having a Dye component, wherein the Dye component can be activated by light to form an active form capable of damaging tissue through a type I mechanism or a type II mechanism. The present invention also discloses compositions or formulations comprising at least two of these compounds which, when administered to a patient and activated by light, will destroy tissue by either a Type I mechanism or a Type II mechanism or both, depending on which of the compounds is selected. specific Dye and / or activation wavelength. The compounds may contain targeting moieties, which may contain one or more epitopes and target sites, the compounds are targeted to specific physiological or anatomical sites for site-specific phototherapy. These can be used in the phototherapy of tumors and other lesions, or in the optical diagnosis of tumors and other lesions, and in the phototherapy of tumors for an appropriate time before the bioconjugate is clea...

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Abstract

The invention discloses compounds and compositions for dual phototherapy and combined therapy and diagnosis of tumors and other lesions. The compounds have a Dye that, when photoactivated, operates via Type I and / or Type II mechanisms. Other Dye or azide components may operate by the same or different mechanisms. Selection of particular components in a compound, and formulation of the compound(s) in a composition permit different activation wavelengths to be used for different therapies. A targeting moiety may be added to the compound or composition so that the Dye locates at a particular site, such as a hormone-sensitive tumor, for diagnosis and / or treatment. The compounds and compositions may be incorporated within liposomes.

Description

[0001] Cross References to Related Applications [0002] This application is a continuation-in-part of currently pending US Patent Application Serial No. 09 / 898,885 filed July 3, 2001, the disclosure of which is incorporated herein by reference in its entirety. field of invention [0003] The present invention generally relates to novel compounds useful in dual photodiagnostic and phototherapeutic procedures. Background of the invention [0004] The use of visible and near-infrared (NIR) light in clinical practice is growing rapidly. Compounds that absorb or emit in the visible or near infrared or long wavelength (UV-A, >350nm) region of the electromagnetic spectrum are potentially useful in optical tomography, endoscopy and phototherapy. However, the main advantage of biomedical optics lies in its therapeutic potential. Phototherapy has been shown to be a safe and effective method for treating various surface injuries (external and internal). Its efficacy is similar t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09B47/00A61K49/00C07D277/64A61K31/409A61K31/428A61K41/00A61K45/00A61K47/48A61P9/10A61P35/00A61P43/00C07D487/22C09B47/04
CPCA61K47/48069Y10S436/80A61K47/48346C09B23/083A61K41/0057C09B47/30C09B47/045B82Y5/00A61K41/0061A61K41/0076A61K41/0071A61K47/546A61K47/66Y10T436/13A61P35/00A61P43/00A61P9/10
Inventor 塞缪尔·阿基莱夫拉加万·拉杰戈帕兰理查德·B·多肖约瑟夫·E·巴加穆萨娜达·P·佩里阿萨米
Owner MALLINCKRODT INC
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