Glycerophospholipids containing omega-3 and omega-6 fatty acids

A technology of glycerophospholipids and unsaturated fatty acids, which can be used in medical preparations containing active ingredients, food science, digestive system, etc., and can solve problems such as strong fishy smell

Inactive Publication Date: 2007-01-17
ENZYMOTEC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Despite the health image, one issue perceived

Method used

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  • Glycerophospholipids containing omega-3 and omega-6 fatty acids
  • Glycerophospholipids containing omega-3 and omega-6 fatty acids
  • Glycerophospholipids containing omega-3 and omega-6 fatty acids

Examples

Experimental program
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preparation example Construction

[0163] The preparation of pharmaceutical compositions is well known in the art and is described in numerous documents and reference works, see for example Gennaro A.R. ed. (1990) Remington's Pharmaceutical Sciences, Mack Publishing Company, Easton, Pennsylvania, especially pages 1521-1712 therein .

[0164] As a food additive, the preparation of the present invention can be used in the form of soft capsules, tablets, syrups or any other common dietary supplement delivery system.

[0165] As a functional food, the product of the present invention can be incorporated and used in various foods such as dairy products, ice cream, biscuits, soy products, pastries and breads, soy sauces, seasonings, oils and fats, margarines, sauces, cereals, Beverages and mixed drinks, infant formula, baby food (biscuits, purees and fruit purees, cereals), food bars, snacks, confectionery, chocolate products.

[0166] As a pharmaceutical product, the preparation of the present invention can be deli...

Embodiment 1

[0180] method

[0181] animals and feed

[0182] Male Wistar rats originating from the same population were obtained by Harlen. 50 rats were randomly divided into 5 feed supplement groups. In addition to normal feed, there were: (i) a group (MCT group) fed with 0.1g medium-chain triglyceride (MCT) / 1ml supplementary matrix; (ii) ) group fed 0.1 g DHA / EPA (20 / 30% total fatty acid composition, diluted with MCT, yielding 30% (w / w) LC-PUFA compound) triglycerides / 1 ml supplemented matrix (LC-PUFA group); ( iii) a group fed with 0.1 g of soybean lecithin-derived PS (20% SB-PS w / w) / 1 ml of supplemented matrix (SB-PS group); and (iv) fed with 0.1 g of PS-ω3 (20% PS W / W, 30% of total LC-PUFA composition) / l ml group supplemented with matrix (PS group). Supplemented matrix was stored at -20°C and rats were fed fresh portions daily. All supplements are processed to minimize fatty acid oxidation. Rats were given feed and water ad libitum. All rats were housed in a standard environmen...

Embodiment 2

[0203] Embodiment 2-PS-ω3 treats ADHD child

[0204]Attention-deficit / hyperactivity disorder (ADHD) comprises a broad group of behavioral and learning problems whose definition and diagnosis remain controversial [Kamper (2001) J. Pediatr. 139:173-4; Richardson et al. (2000) Prostaglandins Leukot. Essent . Fatty Acids, 63(1-2):79-87]. The etiology of ADHD is recognized to be complex and multifactorial. ADHD has traditionally been a diagnosis used to describe children who are inattentive, impulsive, and / or hyperactive. Roughly speaking, 20-25% of children with ADHD show a loss of one or more specific learning abilities in mathematics, reading or spelling [Barkley, R.A. (1990) Attenation-deficit hyperactivity disorder: a handbook for diagrzosts arld treatment . New York: Guilford Press]. Children with ADHD often have trouble learning and concentrating and can be disorganized, have poor self-discipline, and have low self-esteem. It is conservatively estimated that 3-5% of the ...

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Abstract

Disclosed is a lipid preparation comprising a glycerophospholipid or salt, conjugate and derivatives thereof, particularly phosphatidylserine (PS), phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidyl-inositol (PI), phosphatidylglycerol (PG) and phosphatidic acid (PA), and poly-unsaturated fatty acid (PUFA) acyl groups, particularly long-chain poly-unsaturated fatty acid (LC-PUFA) acyl groups such as omega-3 and/or omega-6 acyl groups, wherein said PUFA is covalently bound to said glycerophospholipid. The disclosed preparations possess an improved bioactivity, and are useful in the treatment of various cognitive and mental conditions and disorders and for maintenance of normal functions of brain-related systems and processes, for example ADHD.

Description

field of invention [0001] The present invention relates to preparations of phospholipids and polar lipids enriched in omega-3 and / or omega-6 fatty acids covalently attached to the lipid backbone. Specifically, the phospholipid preparation of the present invention can be used as nutritional supplement food, food additive and / or medicament to treat various diseases, especially diseases related to cognitive function. Background of the invention [0002] Lipids, especially polar lipids, nitrogen-containing lipids and carbohydrate-containing lipids (phospholipids, sphingosines, glycolipids, ceramides, sphingomyelin), are the main structural units of cell membranes, tissues, etc. In addition, they also play an important role in signal transduction processes and various biochemical and biosynthetic pathways. [0003] Glycerophospholipids are phospholipids based on a glycerol backbone and containing a phosphate head group, and are the main structural units of cell membranes. Becau...

Claims

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Application Information

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IPC IPC(8): A61K31/683A61K31/685A61P3/10A61P9/10A61P15/12A61P25/00A61P25/16A61P25/22A61P25/28A61P35/00A61P29/00A61P37/00A23L17/20A23L33/00
CPCA61K31/683A61K31/685A61P1/00A61P1/16A61P13/12A61P15/12A61P17/00A61P25/00A61P25/14A61P25/16A61P25/18A61P25/22A61P25/24A61P25/28A61P27/02A61P29/00A61P35/00A61P3/06A61P37/00A61P37/02A61P37/08A61P39/06A61P7/10A61P9/08A61P9/10A61P9/12A61P3/10A23L33/00
Inventor G·本德洛D·普拉特O·法卡什R·佐比Z·巴-安A·舒尔曼D·佩勒德
Owner ENZYMOTEC
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