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Medicinal composition, preparation method and quality control method

A composition and drug technology, which is applied in the direction of drug combination, testing of drug preparations, pharmaceutical formulations, etc., to achieve the effects of convenient use and portability, avoiding disadvantages, and good curative effect

Inactive Publication Date: 2007-02-21
BEIJING QI YUAN YI DE PHARMA RESEARCH CENTER
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there are no reports of preparations that are compatible with both

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Example 1: Preparation of red peony extract: take 10 parts of red peony (parts are: kg or g)

[0030] Take the red peony, crush it into coarse powder, extract twice with 30% ethanol, add 10 times the amount for the first time for 1 hour, and add 8 times the amount for the second time for 0.5 hours. The extract is passed through the treated resin column and washed with water to sugar After the reaction is negative, it can be eluted and adsorbed with 4 times the column volume of 40% ethanol to obtain the red peony extract.

Embodiment 2

[0031] Example 2: Preparation of red peony extract: 1000 parts of red peony (kg or g)

[0032]Take the fine peony powder, put it in a round-bottomed flask, and extract 3 times with 8 times the amount of 70% ethanol under reflux for 1.5 hours each time. The extract is filtered and recovered to dryness under reduced pressure. The residue is dissolved by heating with an appropriate amount of water and filtered. The filtrate is added to a pre-prepared macroporous adsorption resin (the ratio of dry paste to resin is 1:15-20), and after the dripping is completed, the reaction is first eluted with water until the reducing sugar reaction is negative. Use 20% Ethanol elution, the first part is collected separately, then the 20% ethanol eluate is collected, and the last part is collected separately. The middle 20% ethanol eluates are combined, concentrated under reduced pressure to form an extract, and dried in a low-temperature vacuum to obtain a red peony extract.

Embodiment 3

[0033] Example 3: Preparation of red peony extract: 3000 parts of red peony (kg or g)

[0034] Take the red peony, pulverize it into coarse powder, add 13 times the amount of water to decoct 3 times, 2.5h each time, combine the decoction, add ether for deesterification, the water layer is passed through ion exchange resin to remove inorganic impurities and organic acids, and then pass The D140 type macroporous resin adsorption column uses 3 times the amount of 35% ethanol as the eluent, collects the eluent, and concentrates to obtain the red peony extract.

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PUM

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Abstract

A composite medicine in the form of injection or orally taken medicine for treating cardiovascular and cerebrovascular diseases, such as coronary heart disease, angina pectoris, apoplexy sequelae, cerebral thrombus, etc, is prepared from red (or white) peony root or its extract and dipyridamole. Its preparing process and quality control method are also disclosed.

Description

Technical field [0001] The invention provides a pharmaceutical composition for treating cardiovascular and cerebrovascular diseases, and at the same time provides a preparation method and a quality control method of the composition, and belongs to the technical field of medicines. technical background [0002] At present, there are about 4 million deaths from cardiovascular and cerebrovascular diseases in my country each year, with an average of 456 deaths per hour, accounting for more than 3 / 5 of the death toll, and it has become the first cause of death in China. Although drugs for the treatment of cardiovascular and cerebrovascular diseases emerge in different groups, the constant changes in the disease spectrum make the current drugs continue to show their limitations. For this reason, the research and development of this major disease of cardiovascular and cerebrovascular diseases has always been the focus of attention. And hot spots. In the prior art, the active ingredient ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/71A61K9/00A61P9/10A61P7/02G01N33/15A61K31/519
Inventor 于文风
Owner BEIJING QI YUAN YI DE PHARMA RESEARCH CENTER