New combinations of an anti emetic agent and an enkephalinase inhibitor
An antiemetic and a composition technology, which is applied in the field of combination of an antiemetic and an enkephalinase inhibitor, can solve the problems of no suggestion or assumption, can not be used, etc., and achieves optimal single administration and optimal pharmacokinetics. , the effect of improving the effect of single administration
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[0080] Example: In Vivo Activity of Combinations of the Invention
[0081] The outstanding activity of the combination according to the invention was confirmed in an animal model of experimental diarrhea. According to Niemegeers et al. (Armeim.-Forsch. (Drug Res), 1974, 24 The method of No. 10), evaluating the combination of the present invention with castor oil-induced diarrhea in rats.
[0082] Rats received a combination of ondansetron (0.1 mg / kg, p.o.) and racecadotril (40 mg / kg, p.o.). The combination elicited a nearly complete antidiarrheal effect for 6-7 hours.
[0083] In Comparative Example, ondansetron and racecadotril were administered alone at the same dose.
[0084] Ondansetron (0.1 mg / kg, p.o.) was not active in this model when administered alone.
[0085] Administration of racecadotril (40 mg / kg, p.o.) alone induced partial protection for 4 hours in this model.
[0086] In addition, ondansetron at 1 mg / kg was also inactive in this model, but when combined ...
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