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Collagen base bionic bone matrix

A collagen and biomimetic mineralization technology, used in bone implants, medical science, prostheses, etc., to overcome the existing effects

Active Publication Date: 2007-02-28
TIANJIN SANNIE BIOENG TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But until today, there is still no better material than heterogeneous bone and homogeneous bone in clinical practice.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Take 100g of calcium carbonate in a crucible, calcined at 1050°C for 3 hours to obtain calcium oxide, and place it in a desiccator for later use. Take 1.12 g of calcium oxide obtained by calcining calcium carbonate, dissolve it in 200 ml of deionized water under nitrogen protection, stir overnight to make it fully nitrify into a suspension of calcium hydroxide for later use. Take fresh collagen equivalent to 1g of dry collagen, dissolve and disperse it in 120ml, 0.1mol / L phosphoric acid solution to make a 200ml solution, wherein the content of collagen is 5mg / ml, and the concentration of phosphoric acid is 0.06mol / L. Take a 1000ml beaker as the reactor of the self-assembly system, first add 200ml of deionized water, keep the temperature at 40±2°C, add the calcium hydroxide suspension and collagen / phosphoric acid solution prepared above dropwise into the reactor and Stir continuously, and use a pH meter to control the pH value of the reaction system at 9±0.1 during the d...

Embodiment 2

[0013] Take commercially available Ca(OH) 2 5.6g, dissolved in 750ml of deionized water under nitrogen protection, stirred overnight to make it fully nitrified into a suspension of calcium hydroxide for later use. Take fresh collagen equivalent to 4.1g of dry collagen, dissolve and disperse it in 450ml, 0.1mol / L phosphoric acid solution to form a 750ml solution, wherein the content of collagen is 5.5mg / ml, and the concentration of phosphoric acid is 0.06mol / L. Take a 3000ml beaker as the reactor of the self-assembly system, first add 300ml of deionized water, keep the temperature at 35±2°C, add the calcium hydroxide suspension and collagen / phosphoric acid solution prepared above dropwise into the reactor and Stir constantly, use a pH meter to control the pH value of the reaction system at 10±0.1 during the dropping process, there should be flocculent precipitates during the dropping process, and wind up on the stirring plate, continue to react and stir for 12 hours after the d...

Embodiment 3

[0015] Commercially available CaCl 2 11.1 g, dissolved in 1500 ml deionized water under nitrogen protection, stirred overnight to make it into a suspension for later use. Take fresh collagen equivalent to 10g of dry collagen, dissolve and disperse it in 900ml, 0.1mol / L phosphoric acid solution to make a 1500ml solution, wherein the content of collagen is 6.7mg / ml, and the concentration of phosphoric acid is 0.06mol / L. Take a 3000ml beaker as the reactor of the self-assembly system, first add 300ml of deionized water, keep the temperature at 25±2°C, add the calcium hydroxide suspension and collagen / phosphoric acid solution prepared above dropwise into the reactor and Stir constantly, use a pH meter to control the pH value of the reaction system at 8±0.1 during the dropping process, there should be flocculent precipitates during the dropping process, and wind up on the stirring plate, continue to react and stir for 12 hours after the dropping, filter and wash the precipitate , ...

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PUM

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Abstract

The invention discloses a clinical bone filling, restoring and replacing material in the medical biological material domain, which is characterized by the following: I-typed collagen and Ca<2+> mineralize artificially and assemble automatically, possessing excellent biological compatibility.

Description

technical field [0001] The invention relates to a composite material of collagen and hydroxyapatite and a manufacturing method thereof. For bone filling, repair and replacement. The invention belongs to the technical field of medical biomaterials. Background technique [0002] The research on human bone repair and replacement materials started earlier. It started with people trying to repair the defects of bones and teeth with wicker, ivory and stones. The application of metal materials and the clinical use of medical polymer materials and the subsequent use of some inert ceramic materials have entered the stage of nanocomposite materials. But until today, there is still no better material than heterogeneous bone and homogeneous bone in clinical practice. However, both heterogeneous bone and homogeneous bone have limited sources, high rejection, and the risk of infecting other diseases to varying degrees. Through the study of human bone structure, it is found that the m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/46A61F2/28
Inventor 毕宏伟谢磊
Owner TIANJIN SANNIE BIOENG TECH
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