Preparation method and application of cortex fraxini extract

A technology of Qinpi and its uses, which is applied in the field of preparation of Chinese medicine Qinpi extract, which can solve the problems of loss, decrease of pharmacological activity and clinical effect, and reduction of curative effect

Active Publication Date: 2007-03-07
四川恩威制药有限公司
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  • Abstract
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Problems solved by technology

However, the so-called total coumarins obtained by this method are actually only alopecia, and the other several coumarins in the original medicinal materials are basically lost, and their pharmacological activity and clinical effect are significantly reduced.
[0004]Traditional Chinese medicine tre

Method used

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  • Preparation method and application of cortex fraxini extract
  • Preparation method and application of cortex fraxini extract

Examples

Experimental program
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Embodiment 1

[0047] Take 100 kg of bark of Qinpi branches, cut into filaments, add water to decoct and extract 3 times, add 1000 liters of water each time, decoct for 1.5 hours, combine the extracts, filter, combine the extracts three times, and concentrate to a relative density of about 1.1 (60 ℃ thermal measurement), add ethanol to make the alcohol content reach 80%, let it stand, filter, the filtrate decompresses and recovers ethanol until it has no alcohol smell, adds 100 liters of water to dissolve, and adds it to the D101 type macroporous adsorption resin column that has been treated First, rinse with 300 liters of water, discard the washing liquid, and then elute with 600 liters of 50% ethanol, collect the 50% ethanol eluate, recover the ethanol until it has no alcohol smell, and concentrate to a relative density of about 1.38 (60 ℃ thermal measurement ), dried in a vacuum, pulverized, passed through a 80-mesh sieve, and mixed uniformly to obtain 7.12 kg of coumarin composition, calc...

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PUM

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Abstract

The invention relates to a method for preparing ash bark coumarin compound. Wherein, it boils and extracts with water, uses porous resin to separate and purify ash bark coumarin compound; and said compound comprises aesculin, aesculetin, fraxin, and fraxetin, while the total coumarin content is higher than 50%, and the contents of aesculin, aesculetin, fraxin, and fraxetin are higher than 40%, while their ratios are 4-6:1-3:2-4:1. The invention also provides its application in medicine production.

Description

technical field [0001] The invention relates to a preparation method and application of a traditional Chinese medicine bark chinensis extract, more specifically a total coumarin mixture extracted and purified from bark bark chinensis, its preparation method and pharmaceutical application. Background technique [0002] Qin bark is the dry bark or branch bark of Fraxinus rhynchophylla Hance, Fraxinus chinensis Roxb., Fraxinus chinensis Roxb. var. acuminata Lingelsh. or Fraxinus stylosa Lingelsh. Aesculin (aesculin), aesculetin (aesculetin), aesculin (fraxin), and fraxetin (fraxetin) represent coumarin components, etc., although it has been reported in the literature that aesculin has anti-inflammatory and analgesic properties It is clinically used for hyperuricemia and acute attack of gouty arthritis. There are also literature reports on the anti-inflammatory, analgesic and uric acid pharmacological activities of aurocetine, aurocetine B, and urocetidin, but for quincetin The...

Claims

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Application Information

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IPC IPC(8): A61K31/37A61K31/7048A61K36/185A61P19/06
Inventor 杨奎
Owner 四川恩威制药有限公司
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