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Process of preparing dioscin with dioscin penicillium notatum

A technology of penicillium diosgenin and diosgenin, applied in the field of diosgenin preparation, can solve the problems of large amount, affecting the health of saponin production personnel, environmental and river pollution, etc., and reduce production energy consumption and production cost Effect

Inactive Publication Date: 2007-03-21
WUHAN BOTANICAL GARDEN CHINESE ACAD OF SCI
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Problems solved by technology

Therefore, acidic organic wastewater pollutants will inevitably be produced, and the total amount is very large, and the cost of sewage treatment is very high, which directly affects the health of saponin production personnel. The environment and rivers in the area have caused serious pollution

Method used

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Effect test

Embodiment 1

[0027] The method for preparing dioscin from Penicillum dioscin 051016 (Penicillum dioscin 051016) CCTCC No: M206001 is carried out according to the following steps.

[0028] 1. Clean the yam raw material;

[0029] 2. Crushing the raw material to less than 5mm;

[0030] 3. Sterilize directly at 100°C for 0.5-1 hour, or add 0.5% ammonia water by weight of raw materials, mix well, and place at 25°C-28°C for 1 hour;

[0031] 4. Add Penicillumdioscin 051016, CCTCC No: M206001, with 0.1% weight of raw materials at 25°C-28°C, stir evenly, and ferment at 25°C-28°C for 24-36 hours under the condition of pH 4-7;

[0032] 5. Add water that is 4 times the weight of the fermentation material;

[0033] 6. Stir and filter, dry the filter residue at 60°C to 70°C, then add petroleum ether with a boiling range of 60°C to 90°C that is 3 to 5 times the weight of the filter residue;

[0034] 7. Reflux extraction at 60°C for 2 to 3 times, and combine the extracts;

[0035] 8. Recover petroleum...

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Abstract

The present invention is process of preparing dioscin with Penicillium dioscin 051016 in the preservation number of CCTCC No. M206001. The preparing process includes the following steps: crushing Chinese yam, sterilizing, mixing with Penicillium dioscin, fermenting at pH4-7 and 25-28 deg.c for 24-36 hr, reflux extracting with petroleum ether, crystallizing and drying to obtain dioscin. Compared with available technology, the present invention has the advantages of no production of acid organic effluent pollutant and normal temperature fermentation in low power consumption and low production cost.

Description

Technical field: [0001] The invention relates to the preparation of diosgenin, and more specifically relates to the preparation of diosgenin by the fermentation method of Penicillium diosgenin. Diosgenin is the main raw material for the production of steroid hormones. Background technique: [0002] Dioscin is extracted from plants of the genus Dioscorea, and turmeric is the main resource for extracting diosgenin. There are more than 200 kinds of synthetic drugs using diosgenin as raw materials, among which more than 60% of steroid hormones use diosgenin as raw materials. [0003] The traditional method of extracting diosgenin from yam raw material is acid hydrolysis. The extraction process using the acid hydrolysis method will produce a large amount of acidic organic wastewater to pollute the environment and rivers in the production area, and the sewage treatment will greatly increase the production cost. Therefore, people have been trying to replace acid hydrolysis with ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12P33/20C12R1/80
Inventor 卢大炎张丽红叶晚成王艳军
Owner WUHAN BOTANICAL GARDEN CHINESE ACAD OF SCI
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