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Stasis-expelling drop pills for treating coronary heart disease, angina cordis and high blood fat and thereof making method

A technology for coronary heart disease angina pectoris and hyperlipidemia, which is applied in the field of traditional Chinese medicine preparations and can solve problems such as dripping pills that have not yet been seen.

Active Publication Date: 2007-06-20
TIANJIN HONGRENTANG PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no drop pill dosage form yet

Method used

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  • Stasis-expelling drop pills for treating coronary heart disease, angina cordis and high blood fat and thereof making method
  • Stasis-expelling drop pills for treating coronary heart disease, angina cordis and high blood fat and thereof making method
  • Stasis-expelling drop pills for treating coronary heart disease, angina cordis and high blood fat and thereof making method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0264] prescription:

[0265] Peach kernel (stir-fried) 0.25kg Angelica 0.15kg Fructus aurantium (stir-fried bran) 0.1kg Chuanxiong 0.075kg

[0266] Bupleurum 0.05kg Safflower 0.15kg Achyranthes Bidentata 0.15kg Red Peony 0.18kg

[0267] Rehmannia 0.15kg Platycodon grandiflorum 0.075kg Licorice 0.5kg

[0268] Extract 2ml of volatile oil from 11 medicinal materials according to the prescription, extract 3 times of medicinal residues with water, add 6 times the amount of water, respectively, 1 hour of decocting time, filter, medicinal residues ① set aside, combine the filtrate, concentrate under reduced pressure to relative 1.38 kg of extract with a density of 1.16 (measured at 75°C), add ethanol to make the alcohol content 60%, stir well, let stand for 24 hours to precipitate, take the supernatant to recover the ethanol, and concentrate under reduced pressure to a relative density of 1.30 (70 Measured at ℃) 0.62kg ②, ready for use; extract the drug residue ① with 80% ethanol twice,...

Embodiment 2

[0270] prescription:

[0271] Peach kernel (fried) 0.25kg Angelica 0.15kg Fructus aurantium (fried bran) 0.1kg Chuanxiong 0.075kg

[0272] Bupleurum 0.05kg Safflower 0.15kg Achyranthes Bidentata 0.15kg Red Peony 0.18kg

[0273] Rehmannia 0.15kg Platycodon grandiflorum 0.075kg Licorice 0.5kg

[0274] Extract 11 medicinal materials with water twice according to the prescribed amount, add 8 times the amount of water, decoct for 1 hour, filter, combine the filtrate, and concentrate under reduced pressure to 1.24 kg of extract with a relative density of 1.18 (measured at 75°C). Add ethanol to make the alcohol content 70%, stir well, let stand for 24h to precipitate, take the supernatant to recover the ethanol, concentrate under reduced pressure to 0.35kg of the clear paste with a relative density of 1.30 (measured at 70°C); use 1 times the amount again Extracted 4 times with ethyl acetate, combined the extracts, recovered ethyl acetate, concentrated under reduced pressure to 0.014 kg o...

Embodiment 3

[0276] prescription:

[0277] Peach kernel (fried) 0.25kg Angelica 0.15kg Fructus aurantium (fried bran) 0.1kg Chuanxiong 0.075kg

[0278] Bupleurum 0.05kg Safflower 0.15kg Achyranthes Bidentata 0.15kg Red Peony 0.18kg

[0279] Rehmannia 0.15kg Platycodon grandiflorum 0.075kg Licorice 0.5kg

[0280]According to the prescription, extract 11 medicinal materials with 80% ethanol twice, add 7 times the amount of ethanol for the first time, decocting for 2 hours, and collect the filtrate; add 5 times the amount of ethanol for the second time, decocting for 1 hour, collect the filtrate, and combine the two Sub-filtrate. Then the filtrate was concentrated under reduced pressure to 1.02 kg of extract with a relative density of 1.15 (measured at 70°C), extracted twice with 1 times the amount of ethyl acetate, and ethyl acetate was recovered, and concentrated under reduced pressure to a relative density of 1.20 (70°C) (Determined) 0.007kg of clear ointment ①, spare. Extract the dregs after ...

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PUM

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Abstract

A Chinese medicine in the form of dripping pill for treating coronary heart disease, angina pectoris and hyperlipemia is prepared from PEG6000 as matrix and 11 Chinese- medicinal materials including peach kernel, Chinese angelica root, Chuan-xiong rhizome, safflower, etc. Its preparing process is also disclosed.

Description

[0001] The present invention is a divisional application with the application date of September 5, 2005, application number 200510014981.6, and the title of the invention "Xuefu Zhuyu dripping pill for the treatment of coronary heart disease, angina pectoris and hyperlipidemia and its preparation method". Technical field [0002] The invention belongs to the technical field of traditional Chinese medicine preparations, and particularly relates to a Xuefu Zhuyu dripping pill for treating coronary heart disease, angina pectoris and hyperlipidemia, and a preparation method thereof. Background technique [0003] Xuefu Zhuyu Capsule is a classic Chinese patent medicine, WS standard by the Ministry of Health 2 -B-0928-91 records the prescription: [0004] Peach kernel (stir-fried) 200g Angelica 150g Fructus aurantii (stir-fried bran) 100g Chuanxiong 75g [0005] Bupleurum 50g, safflower 150g, achyranthes 150g, red peony 100g [0006] Rehmannia 150g Platycodon 75g Licorice 50g [0007] F...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/804A61K9/20A61P9/10A61P3/06
Inventor 朱晓晶马洪波李永仓李凤阁杨静赵喆
Owner TIANJIN HONGRENTANG PHARM CO LTD