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Preparation of shikimic acid

A technology of shikimic acid and technology, applied in the field of plant resources, can solve the problems of long industrialized production process, complicated operation and high cost

Inactive Publication Date: 2007-06-20
邓薏
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the strong polarity and small molecular weight of shikimic acid, and the star anise fruit contains a large amount of sugar and a large amount of volatile oil (2-6%), it is not easy to extract, separate and purify, and the extract and extract need to be degreased, etc., and the industrial production process is long. , high equipment requirements, complex operation, relatively high cost
In addition, due to the large demand for shikimic acid at home and abroad, although my country's star anise production accounts for 80% of the world, it is far from meeting the needs of disease prevention and control. Roche Pharmaceuticals, the patent owner of the anti-bird flu drug Tamiflu, also synthesized Tamiflu Insufficient shikimic acid resources as one of the reasons, refused to give up the sole right to use the patent

Method used

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  • Preparation of shikimic acid
  • Preparation of shikimic acid
  • Preparation of shikimic acid

Examples

Experimental program
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Embodiment Construction

[0025] 1. Star anise, crushed, add 10 times the amount of water, stir from time to time, soak for 20 minutes, filter, collect the filtrate; add 8 times the amount of water, 6 times the amount of water to the residue, and operate in the same way. Combine the extracts, evaporate and concentrate to 2:1 (crude drug g / ml), add alcohol to 80% alcohol content, let it stand, filter the supernatant, recover ethanol, decolorize with activated carbon, dry, and the yield of shikimic acid is 4.32% ( Calculated according to shikimic acid, the same below), the content is 38.9%. The residue can be used to extract star anise oil.

[0026] 2. Star anise water steam distills the residue after extracting the star anise oil, filter the water, leave it in place, add 10 times more water to the residue and decoct for 1 hour, filter, combine the two filtrates, concentrate to 2:1 (raw material g / ml), Add alcohol to 80% alcohol content, precipitate, filter, take the filtrate to flow out through D101 ma...

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Abstract

Production of shikimic acid and use of Chinese Star Anise oil residual waste are disclosed. The process is carried out by taking Chinese Star Anise or Chinese Star Anise leaf as raw materials, crushing, decoction extracting by water or agitating to fast extract, depositing by alcohol, removing impurities, de-coloring by active carbon or porous resin, treating by lead acetate or enriching resin while anion-exchanging, crystallizing and re-crystallizing to obtain various-purity shikimic acid. It's cheap and convenient and has colorful raw materials.

Description

technical field [0001] The invention relates to a new application of plant resources and a new technique for extracting and preparing shikimic acid. The application of this technology to extract and prepare shikimic acid has the advantages of abundant raw materials, simple and convenient process, and low cost. Background technique [0002] Shikimic acid has significant analgesic and hemodynamic improvement effects, and is also an important raw material for the preparation of various drugs. Today, shikimic acid is extracted from the traditional Chinese medicine star anise, and the fruit of star anise generally contains about 3-8% shikimic acid. It is usually extracted by reflux extraction with high concentration of organic solvents such as methanol, ethanol or acetone, and the extract is separated by organic solvents such as n-butanol, ethyl acetate, etc. or column chromatography, and then obtained by further repeated recrystallization. Due to the strong polarity and small ...

Claims

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Application Information

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IPC IPC(8): C07C51/42C07C62/32
Inventor 邓薏
Owner 邓薏
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